*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YQ9630000
CHEMICAL NAME           : Uracil, 5-diazo-
CAS REGISTRY NUMBER     : 2435-76-9
LAST UPDATED            : 199701
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : C4-H2-N4-O2
MOLECULAR WEIGHT        : 138.10
WISWESSER LINE NOTATION : T6MVMVJ ENUM
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * 5-Diazopyrimidine-2,4(3H)-dione
   * 5-Diazo-2,4(1H,3H)-pyrimidinedione
   * Diazouracil
   * 5-Diazouracil
   * 2,4-Diossi-5-diazopirimidina
   * 2,6-Dioxo-5-diazopyrimidine
   * NSC 23519
   * (1,2,3)Oxadiazolo(5,4-d)pyrimidin-5(4H)-one
   * 2,4(1H,3H)-Pyrimidinedione, 5-diazo-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 30800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986
 
TYPE OF TEST            : LD10 - Lethal Dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 22 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EJCAAH European Journal of Cancer.  (Oxford, UK)  V.1-17(6), 1965-1981. For
   publisher information, see EJCODS.  Volume(issue)/page/year: 10,667,1974
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 10 mg/L
REFERENCE :
   MILEDM Microbios Letters.  (Faculty Press, 88 Regent St., Cambridge, UK)
   V.1-    1976-  Volume(issue)/page/year: 1,169,1976
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 2 mg/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   12,121,1976
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 10 mg/L
REFERENCE :
   MILEDM Microbios Letters.  (Faculty Press, 88 Regent St., Cambridge, UK)
   V.1-    1976-  Volume(issue)/page/year: 1,169,1976
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 10 mg/L
REFERENCE :
   MILEDM Microbios Letters.  (Faculty Press, 88 Regent St., Cambridge, UK)
   V.1-    1976-  Volume(issue)/page/year: 1,169,1976
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 50 umol/L
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   13,187,1981
 
TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 50 umol/L
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   13,187,1981

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***