*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YM3770000
CHEMICAL NAME           : 1-alpha-4,5-alpha-H-Tropanium,
                          3-alpha-hydroxy-8-(p-phenylphenacyl)-, bromide,
                          (-)-tropate
CAS REGISTRY NUMBER     : 5868-06-4
LAST UPDATED            : 199103
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C31-H34-N-O4.Br
MOLECULAR WEIGHT        : 564.57
WISWESSER LINE NOTATION : T56 A AKTJ A1VR DR&& A1 GOVYR&1Q &E -(-)TROPATE
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * FA 402
   * Fentonium bromide
   * 3-alpha-Hydroxy-8-(p-phenylphenacyl)-1-alpha-H,5-alpha-H-tropanium  
   bromide (-)-tropate
   * Ketoscilium
   * Phentonium bromide
   * N-(4-Phenylphenacyl)-1-hyoscyaminium bromide
   * Ulcesium
   * Z 326
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 11600 ug/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #3356682
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #3356682
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #3356682
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 12100 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #3356682
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #3356682
 
                            *** END OF RECORD ***