*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YR7350000
CHEMICAL NAME           : Urea, 1-((p-acetylphenyl)sulfonyl)-3-cyclohexyl-
CAS REGISTRY NUMBER     : 968-81-0
BEILSTEIN REFERENCE NO. : 2225115
LAST UPDATED            : 199806
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C15-H20-N2-O4-S
MOLECULAR WEIGHT        : 324.43
WISWESSER LINE NOTATION : L6TJ AMVMSWR DV1
COMPOUND DESCRIPTOR     : Tumorigen
                          Drug
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * Acetohexamide
   * 1-(p-Acetylbenzenesulfonyl)-3-cyclohexylurea
   * 1-((p-Acetylphenyl)sulfonyl)-3-cyclohexylurea
   * Benzenesulfonamide, 4-acetyl-N-((cyclohexylamino)carbonyl)-
   * Dimelin
   * Dimelor
   * Dymelor
   * Gamadiabet
   * Hypoglicil
   * Metaglucina
   * Minoral
   * NCI-C03247
   * Ordimel
   * Tsiklamid
   * U 14812
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,34,1995
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >2500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,18,1982
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE                    : 900 mg/kg
SEX/DURATION            : female 26-39 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - stillbirth
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   2,187,1964

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 83998
       No. of Facilities: 33 (estimated)
       No. of Industries: 1
       No. of Occupations: 2
       No. of Employees: 627 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 83998
       No. of Facilities: 43 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 1626 (estimated)
       No. of Female Employees: 833 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-50,78

 
                            *** END OF RECORD ***