*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : YS2761700 CHEMICAL NAME : Urea, N-(2,6-bis(1-methylethyl)phenyl)-N'-((1-(4-(dimethyla mino)phenyl)cyclopent yl)methyl)-, monohydrochloride CAS REGISTRY NUMBER : 133825-81-7 LAST UPDATED : 199706 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C27-H39-N3-O.Cl-H MOLECULAR WEIGHT : 458.15 COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * N-(2,6-Bis(1-methylethyl)phenyl)-N'-((1-(4-(dimethylamino)phenyl)cyclope ntyl)methyl)urea HCl * PD 132301-2 *** HEALTH HAZARD DATA *** ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 168 mg/kg/2W-I TOXIC EFFECTS : Endocrine - other changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - changes in phosphorus REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 20,217,1993 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 350 mg/kg/2W-I TOXIC EFFECTS : Endocrine - other changes Skin and Appendages - other glands REFERENCE : TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 22,510,1994 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 700 mg/kg/7D-I TOXIC EFFECTS : Endocrine - other changes REFERENCE : TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 21,54,1993 *** END OF RECORD ***