*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : YS4906350 CHEMICAL NAME : Urea, N-(2-chloroethyl)-N'-(2,6-dihydroxycyclohexyl)-N-nitr oso-, (1-alpha,2-beta,6-beta)- CAS REGISTRY NUMBER : 58484-17-6 LAST UPDATED : 198610 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C9-H16-Cl-N3-O4 MOLECULAR WEIGHT : 265.73 WISWESSER LINE NOTATION : L6TJ AQ BMVNNO&2G CQ COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * N-(2-Chloroethyl)-N'-(2,6-dihydroxycyclohexyl)-N-nitrosourea * trans-1-(2-Chloroethyl)-3-(2,6-dihydroxycyclohexyl)-1-nitrosourea * 2-((((2-Chloroethyl)nitrosoamino)carbonyl)amino)-1,3-cyclohexanediol * trans,trans-2,6-Dihydroxy-ccnu * DONU * NSC 264395 * Urea, 1-(2-chloroethyl)-3-(2,6-dihydroxycyclohexyl)-1-nitroso-, (E)- *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 33010 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 11500 ug/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 6,25,1981 *** END OF RECORD ***