*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : YS4981000 CHEMICAL NAME : Urea, 1-(2-chloroethyl)-3-(beta-D-glucopyranosyl)-1-nitroso - CAS REGISTRY NUMBER : 58484-07-4 LAST UPDATED : 199112 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C9-H16-Cl-N3-O7 MOLECULAR WEIGHT : 313.73 WISWESSER LINE NOTATION : T6OTJ BMVNNO&2G CQ DQ EQ F1Q -B,D-GLU COMPOUND DESCRIPTOR : Mutagen SYNONYMS/TRADE NAMES : * 1-(2-Chloroethyl)-3-(beta-D-glucopyranosyl)-1-nitrosourea * GANU * NSC D 254157 *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 40 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP. Volume(issue)/page/year: 68,247,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 15 mg/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 37,783,1977 TYPE OF TEST : LD10 - Lethal Dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 10 mg/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : ANBCB3 Antibiotics and Chemotherapy (Basel). (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.17- 1971- Volume(issue)/page/year: 23,64,1978 ** MUTATION DATA ** TYPE OF TEST : Gene conversion and mitotic recombination TEST SYSTEM : Yeast - Saccharomyces cerevisiae DOSE/DURATION : 1 mmol/L/16H REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 42,45,1977 TYPE OF TEST : DNA damage TEST SYSTEM : Rodent - mouse Leukocyte DOSE/DURATION : 100 umol/L REFERENCE : INSSDM INSERM Symposium. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) No.1- 1975- Volume(issue)/page/year: 19,49,1981 TYPE OF TEST : DNA damage TEST SYSTEM : Rodent - mouse Bone marrow DOSE/DURATION : 100 umol/L REFERENCE : INSSDM INSERM Symposium. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) No.1- 1975- Volume(issue)/page/year: 19,49,1981 TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - mouse Leukocyte DOSE/DURATION : 10 mg/kg REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 37,783,1977 TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - mouse Leukocyte DOSE/DURATION : 10 umol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 37,783,1977 *** END OF RECORD ***