*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : YS4983500 CHEMICAL NAME : Urea, 1-(2-chloroethyl)-3-(trans-4-hydroxycyclohexyl)-1-nit roso- CAS REGISTRY NUMBER : 56239-24-8 LAST UPDATED : 199410 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C9-H16-Cl-N3-O3 MOLECULAR WEIGHT : 249.73 WISWESSER LINE NOTATION : L6TJ AQ DMVNNO&2G -TRANS COMPOUND DESCRIPTOR : Drug Mutagen SYNONYMS/TRADE NAMES : * N-(2-Chloroethyl)-N'-(trans-4-hydroxycyclohexyl)-N-nitrosourea * 1-(2-Chloroethyl)-3-(trans-4-hydroxycyclohexyl)-1-nitrosourea * trans-4-Hydroxy-ccnu * NSC-239717 * trans-4-OH CCNU * Urea, N-(2-chloroethyl)-N'-(4-hydroxycyclohexyl)-N-nitroso-, trans- *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 52420 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986 TYPE OF TEST : LD10 - Lethal Dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 12 mg/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : ANBCB3 Antibiotics and Chemotherapy (Basel). (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.17- 1971- Volume(issue)/page/year: 23,64,1978 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intrapleural SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 35 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 18,634,1975 ** MUTATION DATA ** TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 100 nmol/plate REFERENCE : JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 65,149,1980 TYPE OF TEST : DNA damage TEST SYSTEM : Human Embryo DOSE/DURATION : 100 umol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 44,1352,1984 *** END OF RECORD ***