*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : YS4986000
CHEMICAL NAME : Urea, 1-(2-chloroethyl)-3-(2-hydroxyethyl)-1-nitroso-
CAS REGISTRY NUMBER : 60784-46-5
BEILSTEIN REFERENCE NO. : 1956525
LAST UPDATED : 199612
DATA ITEMS CITED : 15
MOLECULAR FORMULA : C5-H10-Cl-N3-O3
MOLECULAR WEIGHT : 195.63
WISWESSER LINE NOTATION : Q2MVNNO&2G
COMPOUND DESCRIPTOR : Tumorigen
Drug
Mutagen
SYNONYMS/TRADE NAMES :
* 1-(2-Chloroethyl)-3-(2-hydroxyethyl)-1-nitrosourea
* CNU-ethanol
* Elmustina
* Elmustine
* Hecnu
* 1-(2-Hydroxyethyl)-3-(2-chloroethyl)-3-nitrosourea
* Hydroxyethyl CNU
* 1-Nitroso-1-chloroethyl-3-hydroxyethylurea
* NSC-294895
* Urea, N-(2-chloroethyl)-N'-(2-hydroxyethyl)-N-nitroso-
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 25300 ug/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema
Gastrointestinal - ulceration or bleeding from stomach
Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
ONCOBS Oncology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21-
1967- Volume(issue)/page/year: 37,177,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 25 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
INSSDM INSERM Symposium. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt
Ave., New York, NY 10017) No.1- 1975- Volume(issue)/page/year:
19,123,1981
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 16 mg/kg/60W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - tumors
REFERENCE :
DTESD7 52 Vanderbilt Ave., New York, NY 10017) V.1-15, 1977-87.
Discontinued 52 Vanderbilt Ave., New York, NY 10017) V.1- 1977-
Volume(issue)/page/year: 8,273,1980
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 32 mg/kg/60W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Brain and Coverings - tumors
Gastrointestinal - tumors
REFERENCE :
DTESD7 52 Vanderbilt Ave., New York, NY 10017) V.1-15, 1977-87.
Discontinued 52 Vanderbilt Ave., New York, NY 10017) V.1- 1977-
Volume(issue)/page/year: 8,273,1980
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 64 mg/kg/60W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Gastrointestinal - tumors
REFERENCE :
DTESD7 52 Vanderbilt Ave., New York, NY 10017) V.1-15, 1977-87.
Discontinued 52 Vanderbilt Ave., New York, NY 10017) V.1- 1977-
Volume(issue)/page/year: 8,273,1980
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 96 mg/kg/60W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Gastrointestinal - tumors
REFERENCE :
DTESD7 52 Vanderbilt Ave., New York, NY 10017) V.1-15, 1977-87.
Discontinued 52 Vanderbilt Ave., New York, NY 10017) V.1- 1977-
Volume(issue)/page/year: 8,273,1980
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 50 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 178,157,1987
TYPE OF TEST : Phage inhibition capacity
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 1 gm/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 178,157,1987
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 5 mmol/L
REFERENCE :
DRISAA Drosophila Information Service. (Cold Spring Harbor Laboratory, POB
100, Cold Spring Harbor, NY 11724) No.1- 1934- Volume(issue)/page/year:
52,20,1977
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 5 mmol/L
REFERENCE :
DRISAA Drosophila Information Service. (Cold Spring Harbor Laboratory, POB
100, Cold Spring Harbor, NY 11724) No.1- 1934- Volume(issue)/page/year:
52,20,1977
TYPE OF TEST : Gene conversion and mitotic recombination
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 1 mmol/L/16H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 42,45,1977
TYPE OF TEST : DNA damage
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 100 umol/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
44,514,1984
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - mouse Lung
DOSE/DURATION : 1 mg/L/1H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 44,87,1977
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
*** END OF RECORD ***