*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : YS5015000
CHEMICAL NAME : Urea, 1-(2-chloroethyl)-1-nitroso-
CAS REGISTRY NUMBER : 2365-30-2
BEILSTEIN REFERENCE NO. : 2246259
LAST UPDATED : 199612
DATA ITEMS CITED : 23
MOLECULAR FORMULA : C3-H6-Cl-N3-O2
MOLECULAR WEIGHT : 151.57
WISWESSER LINE NOTATION : ZVNNO&2G
COMPOUND DESCRIPTOR : Drug
Mutagen
SYNONYMS/TRADE NAMES :
* N-(2-Chloroethyl)-N-nitrosourea
* 1-(2-Chloroethyl)-1-nitrosourea
* CNU
* MP 655
* N-Nitroso-2-chloroethylurea
* 1-Nitroso-1-(2-chloroethyl)urea
* NSC 47547
* SKI 28404
* Urea, N-(2-chloroethyl)-N-nitroso-
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4368 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCISP* National Cancer Institute Screening Program Data Summary,
Developmental Therapeutics Program. (Bethesda, MD 20205)
Volume(issue)/page/year: JAN1986
TYPE OF TEST : LD10 - Lethal Dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4700 ug/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
ANBCB3 Antibiotics and Chemotherapy (Basel). (S. Karger AG, Postfach
CH-4009 Basel, Switzerland) V.17- 1971- Volume(issue)/page/year:
23,64,1978
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 1 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 68,1,1979
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 300 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 202,193,1988
TYPE OF TEST : Phage inhibition capacity
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 2 mg/L
REFERENCE :
APMBAY Applied Microbiology. (Washington, DC) V.1-30, 1953-75. For
publisher information, see AEMIDF. Volume(issue)/page/year: 23,91,1972
TYPE OF TEST : DNA damage
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 1 mmol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 13,425,1992
TYPE OF TEST : DNA damage
TEST SYSTEM : Human Ovary
DOSE/DURATION : 50 umol/L
REFERENCE :
INSSDM INSERM Symposium. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt
Ave., New York, NY 10017) No.1- 1975- Volume(issue)/page/year:
19,33,1981
TYPE OF TEST : DNA damage
TEST SYSTEM : Human Lung
DOSE/DURATION : 50 umol/L
REFERENCE :
INSSDM INSERM Symposium. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt
Ave., New York, NY 10017) No.1- 1975- Volume(issue)/page/year:
19,33,1981
TYPE OF TEST : DNA damage
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 50 umol/L
REFERENCE :
INSSDM INSERM Symposium. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt
Ave., New York, NY 10017) No.1- 1975- Volume(issue)/page/year:
19,33,1981
TYPE OF TEST : DNA damage
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 50 umol/L
REFERENCE :
INSSDM INSERM Symposium. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt
Ave., New York, NY 10017) No.1- 1975- Volume(issue)/page/year:
19,33,1981
TYPE OF TEST : DNA damage
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 50 umol/L
REFERENCE :
INSSDM INSERM Symposium. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt
Ave., New York, NY 10017) No.1- 1975- Volume(issue)/page/year:
19,33,1981
TYPE OF TEST : DNA damage
TEST SYSTEM : Human Fibroblast
DOSE/DURATION : 50 umol/L
REFERENCE :
INSSDM INSERM Symposium. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt
Ave., New York, NY 10017) No.1- 1975- Volume(issue)/page/year:
19,33,1981
TYPE OF TEST : DNA damage
TEST SYSTEM : Human Embryo
DOSE/DURATION : 50 umol/L
REFERENCE :
45ZJA3 "Nitrosoureas: Current Status and New Development," Prestayko, A.W.
et al., eds., New York, Academic Press, Inc., 1981 Volume(issue)/page/year:
-,69,1981
TYPE OF TEST : DNA damage
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 50 umol/L
REFERENCE :
45ZJA3 "Nitrosoureas: Current Status and New Development," Prestayko, A.W.
et al., eds., New York, Academic Press, Inc., 1981 Volume(issue)/page/year:
-,69,1981
TYPE OF TEST : DNA damage
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 50 umol/L
REFERENCE :
45ZJA3 "Nitrosoureas: Current Status and New Development," Prestayko, A.W.
et al., eds., New York, Academic Press, Inc., 1981 Volume(issue)/page/year:
-,69,1981
TYPE OF TEST : DNA damage
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 50 umol/L
REFERENCE :
45ZJA3 "Nitrosoureas: Current Status and New Development," Prestayko, A.W.
et al., eds., New York, Academic Press, Inc., 1981 Volume(issue)/page/year:
-,69,1981
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 4 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
48,3100,1988
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - rat Cells - not otherwise specified
DOSE/DURATION : 4 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
48,3100,1988
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - mouse Leukocyte
DOSE/DURATION : 10 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
43,175,1983
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 13200 nmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
38,3379,1978
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 10 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
40,2719,1980
TYPE OF TEST : DNA damage
TEST SYSTEM : Mammal - species unspecified Lymphocyte
DOSE/DURATION : 10 mmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
44,1887,1984
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation
*** END OF RECORD ***