*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YS5075000
CHEMICAL NAME           : Urea, 1-(2-chloroethyl)-1-nitroso-3-(2-norbornyl)-
CAS REGISTRY NUMBER     : 13909-13-2
BEILSTEIN REFERENCE NO. : 2860913
LAST UPDATED            : 199612
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C10-H16-Cl-N3-O2
MOLECULAR WEIGHT        : 245.74
WISWESSER LINE NOTATION : L55 ATJ CMVNNO&2G
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * N'-Bicyclo(2.2.1)hept-2-yl-N-(2-chloroethyl)-N-nitrosourea
   * 1-(2-Chloroethyl)-1-nitroso-3-(2-norbornyl)urea
   * NSC-88106
   * SRI 2638
   * Urea, N'-bicyclo(2.2.1)hept-2-yl-N-(2-chloroethyl)-N-nitroso-
   * Urea, 1-(2-chloroethyl)-3-(2-norbornyl)-1-nitroso-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 83 mg/kg
TOXIC EFFECTS :
   Liver - jaundice, other or unclassified
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   NCIMR* Progress Report Submitted to the National Cancer Institute by Mason
   Research Institute. (Worcester, MA)  Volume(issue)/page/year: -,372,1968
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 56 mg/kg
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   NCIMR* Progress Report Submitted to the National Cancer Institute by Mason
   Research Institute. (Worcester, MA)  Volume(issue)/page/year: -,372,1968
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 54760 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 18750 ug/kg/15D-I
TOXIC EFFECTS :
   Blood - normocytic anemia
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - phosphatases
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - transaminases
REFERENCE :
   NCIMR* Progress Report Submitted to the National Cancer Institute by Mason
   Research Institute. (Worcester, MA)  Volume(issue)/page/year: -,372,1968
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 15 mg/kg/5W-I
TOXIC EFFECTS :
   Liver - change in gall bladder structure or function
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - transaminases
REFERENCE :
   NCIMR* Progress Report Submitted to the National Cancer Institute by Mason
   Research Institute. (Worcester, MA)  Volume(issue)/page/year: -,372,1968
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 35 mg/kg/15D-I
TOXIC EFFECTS :
   Liver - fatty liver degeneration
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   NCIMR* Progress Report Submitted to the National Cancer Institute by Mason
   Research Institute. (Worcester, MA)  Volume(issue)/page/year: -,372,1968
 
                            *** END OF RECORD ***