*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : YS5079000 CHEMICAL NAME : Urea, 1-(2-chloroethyl)-1-nitroso-3-ribofuranosyl-, 5'-(p-nitrobenzoate), 2',3'-cyclic acetal with acetone CAS REGISTRY NUMBER : 55102-44-8 OTHER CAS REGISTRY NOS. : 58779-42-3 LAST UPDATED : 199410 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C18-H21-Cl-N4-O9 MOLECULAR WEIGHT : 472.88 WISWESSER LINE NOTATION : T55 BO DO GOTJ C1 C1 FMVNNO&2G H1OVR DNW COMPOUND DESCRIPTOR : Drug Mutagen SYNONYMS/TRADE NAMES : * Bofumustina * Bofumustine * (Chloro-2-ethyl)-1-(ribofuranosylisopropylidene-2'-3'-paranitrobenzoate- 5')-3-nitrosourea * (Cloro-2-etil)-1-(ribofuranosilisopropilidene-2',3'-paranitrobenzoato)-3 -nitrosourea * I.C.I.G. 1105 * Rfcnu *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 90 mg/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : INSSDM INSERM Symposium. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) No.1- 1975- Volume(issue)/page/year: 19,123,1981 ** MUTATION DATA ** TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 200 ug/plate REFERENCE : INSSDM INSERM Symposium. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) No.1- 1975- Volume(issue)/page/year: 19,165,1981 TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 10 mg/L REFERENCE : FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 36,947,1981 TYPE OF TEST : DNA inhibition TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 10 mg/L REFERENCE : FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 36,947,1981 TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Rodent - mouse Cells - not otherwise specified DOSE/DURATION : 2 mg/L REFERENCE : INSSDM INSERM Symposium. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) No.1- 1975- Volume(issue)/page/year: 19,229,1981 *** END OF RECORD ***