*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YS6615000
CHEMICAL NAME           : Urea, 1-((p-chlorophenyl)sulfonyl)-3-cyclohexyl-
CAS REGISTRY NUMBER     : 963-03-1
BEILSTEIN REFERENCE NO. : 2221686
REFERENCE               : 4-12-00-00056 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C13-H17-Cl-N2-O3-S
MOLECULAR WEIGHT        : 316.83
WISWESSER LINE NOTATION : L6TJ AVMMSWR DG
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Benzenesulfonamide, 4-chloro-N-((cyclohexylamino)carbonyl)-
   * Chlorcyclohexamide
   * Chlorhexamide
   * Chlorocyclamide-R
   * 1-((p-Chlorophenyl)sulfonyl)-3-cyclohexylurea
   * K 694
   * Oradian
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1525 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 25,93,1962
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1525 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 25,93,1962
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1 gm/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   PROEAS Problemy Endokrinologii.  Problems of Endocrinology.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-6, 1936-41; 13-    1967-
   Volume(issue)/page/year: 14,89,1968
 
                            *** END OF RECORD ***