*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YS6630000
CHEMICAL NAME           : Urea, 1-((p-chlorophenyl)sulfonyl)-3-isopropyl-
CAS REGISTRY NUMBER     : 2281-78-9
BEILSTEIN REFERENCE NO. : 2742086
REFERENCE               : 4-11-00-00119 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C10-H13-Cl-N2-O3-S
MOLECULAR WEIGHT        : 276.76
WISWESSER LINE NOTATION : GR DSWMVMY1&1
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Benzenesulfonamide, 4-chloro-N-(((1-methylethyl)amino)carbonyl)-
   * Chlorisopropamide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 153 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
   FRZKAP Farmatsevtichnii Zhurnal (Kiev).  (V/O Mezhdunarodnaya Kniga, 113095
   Moscow, USSR) V.3-    1930-  Volume(issue)/page/year: (6),26,1987
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1 gm/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   PROEAS Problemy Endokrinologii.  Problems of Endocrinology.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-6, 1936-41; 13-    1967-
   Volume(issue)/page/year: 14,89,1968
 
                            *** END OF RECORD ***