*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : CL5629500 CHEMICAL NAME : 2-Azabicyclo(2.2.2)octane, 2-(3-(5-methyl-1,3,4-oxadiazol-2-yl)-3,3-diphenylprop yl)- CAS REGISTRY NUMBER : 57726-65-5 BEILSTEIN REFERENCE NO. : 0939075 LAST UPDATED : 199612 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C25-H29-N3-O MOLECULAR WEIGHT : 387.57 COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * 2-(3,3-Diphenyl-3-(5-methyl-1,3,4-oxadiazol-2-yl)propyl)-2-azabicyclo(2. 2.2)octane * 2-(3-(5-Methyl-1,3,4-oxadiazol-2-yl)-3,3-diphenylpropyl)-2-azabicyclo(2. 2.2)octane * Nufenoxole * SC 27166 * Searle 27166 *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 105 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 1,1,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 21 mg/kg TOXIC EFFECTS : Behavioral - antipsychotic Behavioral - analgesia Gastrointestinal - decreased motility or constipation REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 210,327,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 399 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) REFERENCE : NICHAS Nichidai Igaku Zasshi. Nihon University Medical Journal. (Nihon Daigaku Igakkai, 30, Oyaguchi kami-machi, Itabashi-ku, Tokyo 173, Japan) V.1- 1937- Volume(issue)/page/year: 38,1621,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 95 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) REFERENCE : NICHAS Nichidai Igaku Zasshi. Nihon University Medical Journal. (Nihon Daigaku Igakkai, 30, Oyaguchi kami-machi, Itabashi-ku, Tokyo 173, Japan) V.1- 1937- Volume(issue)/page/year: 38,1621,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 258 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) REFERENCE : NICHAS Nichidai Igaku Zasshi. Nihon University Medical Journal. (Nihon Daigaku Igakkai, 30, Oyaguchi kami-machi, Itabashi-ku, Tokyo 173, Japan) V.1- 1937- Volume(issue)/page/year: 38,1621,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 12 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) REFERENCE : NICHAS Nichidai Igaku Zasshi. Nihon University Medical Journal. (Nihon Daigaku Igakkai, 30, Oyaguchi kami-machi, Itabashi-ku, Tokyo 173, Japan) V.1- 1937- Volume(issue)/page/year: 38,1621,1979 *** END OF RECORD ***