*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CL5446511
CHEMICAL NAME           : 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid,
                          6-(1-hydroxyethyl)-3-((1-(1-iminoethyl)-
                          3-pyrrolidinyl)thio)-7-oxo-,
                          (5R-(3(S*),5-alpha,6-alpha(R*)))-
CAS REGISTRY NUMBER     : 87726-17-8
LAST UPDATED            : 199312
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C15-H21-N3-O4-S
MOLECULAR WEIGHT        : 339.45
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Carbapenem RS-533
   * CS 533
   *   6-(1-Hydroxyethyl)-2-(1-acetimidoylpyrrolidin-3-ylthio)-1-carbaren-2-em-
     3-carboxylic acid
   * Panipenem
   * RS 533
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1300 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - dyspnea
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   39(Suppl 3),140,1991
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 81 gm/kg/90D-I
TOXIC EFFECTS :
   Blood - pigmented or nucleated red blood cells
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - phosphatases
   Related to Chronic Data - death
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   39(Suppl 3),144,1991
 
                            *** END OF RECORD ***