*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CL5446512
CHEMICAL NAME           : 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid,
                          6-(1-hydroxyethyl)-3-((1-(1-iminoethyl)-3-
                          pyrrolidinyl)thio)-7-oxo-,
                          (5R-(3(S*),5-alpha,6-alpha(R*)))- mixed with
                          N-benzoyl-beta- alanine (1:1)
LAST UPDATED            : 199806
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C15-H21-N3-O4-S.C10-H11-N-O3
MOLECULAR WEIGHT        : 532.67
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Panipenem-betamipron mixture
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1629 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - cyanosis
   Lungs, Thorax, or Respiration - other changes
   Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   39(Suppl 3),140,1991
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2196 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,964,1995
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 36 gm/kg/90D-C
TOXIC EFFECTS :
   Blood - pigmented or nucleated red blood cells
   Blood - changes in erythrocyte (RBC) count
   Nutritional and Gross Metabolic - changes in sodium
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   39(Suppl 3),157,1991
 
                            *** END OF RECORD ***