*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CM6800000
CHEMICAL NAME           : 1-Aziridinecarboxylic acid, ethyl ester
CAS REGISTRY NUMBER     : 671-51-2
BEILSTEIN REFERENCE NO. : 0110143
REFERENCE               : 5-20-01-00044 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C5-H9-N-O2
MOLECULAR WEIGHT        : 115.15
WISWESSER LINE NOTATION : T3NTJ AVO2
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Carbamic acid, N,N-ethylene-, ethyl ester
   * N-Carbethoxyethylenimine
   * N-(Ethoxycarbonyl)aziridine
   * 1-Ethoxycarbonylaziridine
   * N-Ethoxycarbonylethyleneimine
   * Ethoxycarbonyl-1-ethylenimine
   * Ethyl aziridinecarboxylate
   * Ethyl 1-aziridinecarboxylate
   * Ethyl aziridinocarboxylate
   * Ethyl 1-aziridinylcarboxylate
   * Ethyl aziridinylformate
   * N,N-Ethyleneurethane
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 8600 ug/kg
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 21,581,1963
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 180 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#04621
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Schizosaccharomyces pombe
DOSE/DURATION           : 29 mmol/L
REFERENCE :
   ADWMAX Abhandlungen der Deutschen Akademie der Wissenschaften zu Berlin,
   Klasse fuer Medizin. (Berlin, Ger. Dem. Rep.)  1950-68.  Discontinued.
   Volume(issue)/page/year: -,193,1962
 
TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 40 mg/kg
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 6,357,1951

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: S pombe-reversion

 
                            *** END OF RECORD ***