*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YT2150000
CHEMICAL NAME           : Urea,
                          1,1'-dithiodiethylenebis(3-(2-chloroethyl)-3-nitroso-
CAS REGISTRY NUMBER     : 77469-44-4
BEILSTEIN REFERENCE NO. : 5158294
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C10-H18-Cl2-N6-O4-S2
MOLECULAR WEIGHT        : 421.36
WISWESSER LINE NOTATION : ONNG2&VM2SS2MVNNO&2G
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * N,N'-Bis((2-chloroethyl)-N-nitrosocarbamoyl)cystamine
   * CNCC
   * Di((chloro-2-ethyl)-2-N-nitroso-N-carbamoyl)-N,N-cystamine
   * 5,6-Dithia-2,9,11-triazatridecanamide,  
   13-chloro-N-(2-chloroethyl)-N,11-dinitroso-10-oxo-
   * 1,1'-Dithiodiethylenebis(3-(2-chloroethyl)-3-nitrosourea)
   * I.C.I.G. 1325
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 280 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   INSSDM INSERM Symposium.  (Elsevier Science Pub. Co., Inc., 52 Vanderbilt
   Ave., New York, NY 10017) No.1-    1975-  Volume(issue)/page/year:
   19,123,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 75 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   INSSDM INSERM Symposium.  (Elsevier Science Pub. Co., Inc., 52 Vanderbilt
   Ave., New York, NY 10017) No.1-    1975-  Volume(issue)/page/year:
   19,123,1981
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 200 ug/plate
REFERENCE :
   INSSDM INSERM Symposium.  (Elsevier Science Pub. Co., Inc., 52 Vanderbilt
   Ave., New York, NY 10017) No.1-    1975-  Volume(issue)/page/year:
   19,165,1981
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 20 mg/L
REFERENCE :
   INSSDM INSERM Symposium.  (Elsevier Science Pub. Co., Inc., 52 Vanderbilt
   Ave., New York, NY 10017) No.1-    1975-  Volume(issue)/page/year:
   19,229,1981
 
                            *** END OF RECORD ***