*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : YT3150000
CHEMICAL NAME : Urea, 1-ethyl-1-nitroso-
CAS REGISTRY NUMBER : 759-73-9
BEILSTEIN REFERENCE NO. : 1761174
REFERENCE : 3-04-00-00233 (Beilstein Handbook Reference)
LAST UPDATED : 199712
DATA ITEMS CITED : 225
MOLECULAR FORMULA : C3-H7-N3-O2
MOLECULAR WEIGHT : 117.13
WISWESSER LINE NOTATION : ZVN2&NO
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* AENH
* Aethylnitroso-harnstoff
* Carbamide, N-ethyl-N-nitroso-
* ENU
* 1-Ethyl-1-nitrosomocovina
* Ethylnitrosourea
* N-Ethylnitrosourea
* N-Ethyl-N-nitroso-urea
* 1-Ethyl-1-nitrosourea
* NEU
* Nitrosoethylurea
* N-Nitroso-N-ethylurea
* NSC 45403
* RCRA waste number U176
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PPTCBY Proceedings of the International Symposium of the Princess Takamatsu
Cancer Research Fund. (Japan Scientific Soc. Press, 6-2-10 Hongo, Bunkyo-ku,
Tokyo 113, Japan) 1st- 1971- Volume(issue)/page/year: 2,73,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 240 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.) V.1-75,
1903-71. For publisher information, see JCROD7. Volume(issue)/page/year:
74,141,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 240 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
V.1- 1869- Volume(issue)/page/year: 222,1064,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 960 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 223,377,1989
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 490 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 223,377,1989
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1 gm/kg/5D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.1- 1955- Volume(issue)/page/year: 22(10),72,1976
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10 mg/kg
female 19 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Brain and Coverings - tumors
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year:
2,93,1976
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 374 mg/kg/2W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - leukemia
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 75,743,1985
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 350 mg/kg
female 16-22 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Brain and Coverings - tumors
REFERENCE :
ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin,
Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see JCROD7.
Volume(issue)/page/year: 81,169,1974
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10 mg/kg
female 15 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Skin and Appendages - tumors
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:
218,682,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 45 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Brain and Coverings - tumors
Skin and Appendages - tumors
REFERENCE :
ANTRD4 Anticancer Research. (5 Argyropoulou St., Kato Patissia, Athens 907,
Greece) V.1- 1981- Volume(issue)/page/year: 4,5,1984
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 5 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 6,769,1985
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 17 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Brain and Coverings - tumors
REFERENCE :
EXPTAX Experimentelle Pathologie (1967-1980). (Jena, Ger. Dem. Rep.)
V.1-18, 1967-80. For publisher information, see EXPADD.
Volume(issue)/page/year: 17,394,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 50 mg/kg
female 15 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Brain and Coverings - tumors
REFERENCE :
ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.) V.1-75,
1903-71. For publisher information, see JCROD7. Volume(issue)/page/year:
73,371,1970
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 5 mg/kg
female 13 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Brain and Coverings - tumors
REFERENCE :
XENOBH Xenobiotica. (Taylor & Francis Ltd., 4 John St., London WC1N 2ET,
UK) V.1- 1971- Volume(issue)/page/year: 3,271,1973
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 20 mg/kg/24W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
72,313,1984
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 9370 ug/kg/50W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
JCROD7 Journal of Cancer Research and Clinical Oncology. (Springer-Verlag
New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.93-
1979- Volume(issue)/page/year: 114,245,1988
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 20 mg/kg
female 19 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Lungs, Thorax, or Respiration - tumors
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.1- 1955- Volume(issue)/page/year: 23(3),41,1977
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 10 mg/kg
female 13 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
49,3620,1989
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 32 mg/kg/4W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year:
52,91,1990
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 100 mg/kg
female 18 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Lungs, Thorax, or Respiration - tumors
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
Volume(issue)/page/year: 17,122,1976
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 58565 ug/kg
female 18 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Blood - leukemia
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60,
1940-78. For publisher information, see JJIND8. Volume(issue)/page/year:
51,1965,1973
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 100 mg/kg
female 53 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Brain and Coverings - tumors
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year:
12,161,1981
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 30 mg/kg
female 59 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Endocrine - tumors
Reproductive - Tumorigenic effects - transplacental tumorigenesis
REFERENCE :
ZAPPAN Zentralblatt fuer Allgemeine Pathologie und Pathologische Anatomie.
(VEB Gustav Fischer Verlag, Postfach 176, Jena DDR-6900, Ger. Dem. Rep.)
V.1- 1890- Volume(issue)/page/year: 121,54,1977
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 610 mg/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Vascular - tumors
Endocrine - thyroid tumors
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
Volume(issue)/page/year: 18,53,1977
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100 mg/kg
female 15-24 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 65,607,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 80 mg/kg
female 25 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
BEXBAN Bulletin of Experimental Biology and Medicine (English Translation).
Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
10013) V.41- 1956- Volume(issue)/page/year: 85,369,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 160 mg/kg
female 25 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
Reproductive - Tumorigenic effects - transplacental tumorigenesis
REFERENCE :
ZAPPAN Zentralblatt fuer Allgemeine Pathologie und Pathologische Anatomie.
(VEB Gustav Fischer Verlag, Postfach 176, Jena DDR-6900, Ger. Dem. Rep.)
V.1- 1890- Volume(issue)/page/year: 121,54,1977
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - pig
DOSE/DURATION : 120 mg/kg
female 20-31 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Skin and Appendages - tumors
REFERENCE :
ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit
Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949-
Volume(issue)/page/year: 34,25,1969
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 60 mg/kg
female 11 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Brain and Coverings - tumors
REFERENCE :
ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.) V.1-75,
1903-71. For publisher information, see JCROD7. Volume(issue)/page/year:
71,320,1968
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 107 mg/kg/20W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin,
Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see JCROD7.
Volume(issue)/page/year: 90,233,1977
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 100 mg/kg
female 16 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Spinal Cord - tumors
Reproductive - Tumorigenic effects - transplacental tumorigenesis
REFERENCE :
AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal
Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1925-
Volume(issue)/page/year: 135,251,1989
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 274 mg/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Gastrointestinal - tumors
Liver - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
43,829,1983
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Peripheral Nerve and Sensation - peripheral nerve tumors
Skin and Appendages - tumors
REFERENCE :
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB
211, 1000 AE Amsterdam, Netherlands) V.76- 1985-
Volume(issue)/page/year: 84,512,1993
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 80 mg/kg
female 15 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Endocrine - tumors
Reproductive - Tumorigenic effects - transplacental tumorigenesis
REFERENCE :
ZAPPAN Zentralblatt fuer Allgemeine Pathologie und Pathologische Anatomie.
(VEB Gustav Fischer Verlag, Postfach 176, Jena DDR-6900, Ger. Dem. Rep.)
V.1- 1890- Volume(issue)/page/year: 121,54,1977
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10 mg/kg
female 21 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Reproductive - Tumorigenic effects - testicular tumors
REFERENCE :
JSONDX Journal of Soviet Oncology. (New York, NY) V.1-5, 1980-84.
Volume(issue)/page/year: 5,396,1984
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 30 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year:
18,131,1983
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 180 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Cardiac - tumors
Gastrointestinal - tumors
REFERENCE :
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of
Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-
Volume(issue)/page/year: 381,250,1982
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 520 mg/kg/1Y-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - tumors
Blood - leukemia
REFERENCE :
PPTCBY Proceedings of the International Symposium of the Princess Takamatsu
Cancer Research Fund. (Japan Scientific Soc. Press, 6-2-10 Hongo, Bunkyo-ku,
Tokyo 113, Japan) 1st- 1971- Volume(issue)/page/year: 2,73,1972
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 20 mg/kg
female 18 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Brain and Coverings - tumors
REFERENCE :
NAGZAC Nagasaki Igakkai Zasshi. Journal of Nagasaki Medical Association.
(Nagasaki Igakkai, c/o Nagasaki Daigaku Igakubu, 12-4 Sakamoto-machi,
Nagasaki 852, Japan) V.1- 1923- Volume(issue)/page/year: 54,130,1979
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 150 mg/kg
female 8-10 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Brain and Coverings - tumors
REFERENCE :
ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin,
Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see JCROD7.
Volume(issue)/page/year: 89,331,1977
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10 mg/kg
female 16 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Brain and Coverings - tumors
REFERENCE :
ANPTAL Acta Neuropathologica. (Springer-Verlag New York, Inc., Service
Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1961-
Volume(issue)/page/year: 34,21,1976
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 20 mg/kg
female 17 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Brain and Coverings - tumors
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year:
1,345,1976
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 70 mg/kg
female 25 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4-
1957- Volume(issue)/page/year: 25,453,1978
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 440 mg/kg
SEX/DURATION : female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 23,981,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 125 mg/kg
SEX/DURATION : female 7-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-
Volume(issue)/page/year: 41,265,1983
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 150 mg/kg
SEX/DURATION : female 7-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-
Volume(issue)/page/year: 41,265,1983
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 100 mg/kg
SEX/DURATION : female 7-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-
Volume(issue)/page/year: 41,265,1983
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 75 mg/kg
SEX/DURATION : female 7-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-
Volume(issue)/page/year: 41,265,1983
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 20 mg/kg
SEX/DURATION : female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
IARCCD IARC Scientific Publications. (Geneva, Switzerland) No.1-26,
1971-78. For publisher information, see IAPUDO. Volume(issue)/page/year:
4,112,1973
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 15 mg/kg
SEX/DURATION : female 18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
Reproductive - Effects on Newborn - behavioral
REFERENCE :
NETOD7 Neurobehavioral Toxicology. (Fayetteville, NY) V.1-2, 1979-80. For
publisher information, see NTOTDY. Volume(issue)/page/year: 2,297,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 40 mg/kg
SEX/DURATION : female 15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes (including
somatic cell genetic material)
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
Switzerland) V.1- 1945- Volume(issue)/page/year: 33,521,1977
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 15 mg/kg
SEX/DURATION : female 18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Effects on Newborn - stillbirth
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
per # born alive)
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
38,1263,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 60 mg/kg
SEX/DURATION : female 18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after birth)
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
38,1263,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE : 30 mg/kg
SEX/DURATION : female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
NAGZAC Nagasaki Igakkai Zasshi. Journal of Nagasaki Medical Association.
(Nagasaki Igakkai, c/o Nagasaki Daigaku Igakubu, 12-4 Sakamoto-machi,
Nagasaki 852, Japan) V.1- 1923- Volume(issue)/page/year: 55,60,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE : 80 mg/kg
SEX/DURATION : female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
IARCCD IARC Scientific Publications. (Geneva, Switzerland) No.1-26,
1971-78. For publisher information, see IAPUDO. Volume(issue)/page/year:
4,127,1973
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE : 80 mg/kg
SEX/DURATION : female 15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
V.1- 1869- Volume(issue)/page/year: 210,1378,1966
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE : 50 mg/kg
SEX/DURATION : female 20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
JONRA9 Journal of Neurochemistry. (Raven Press, 1185 Ave. of the Americas,
New York, NY 10036) V.1- 1956- Volume(issue)/page/year: 29,771,1977
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE : 20 mg/kg
SEX/DURATION : female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o
Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher
information, see CGANE7. Volume(issue)/page/year: 19,81,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE : 20 mg/kg
SEX/DURATION : female 4 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
REFERENCE :
IARCCD IARC Scientific Publications. (Geneva, Switzerland) No.1-26,
1971-78. For publisher information, see IAPUDO. Volume(issue)/page/year:
4,1,1973
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rat
DOSE : 20 mg/kg
SEX/DURATION : female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
IARCCD IARC Scientific Publications. (Geneva, Switzerland) No.1-26,
1971-78. For publisher information, see IAPUDO. Volume(issue)/page/year:
4,112,1973
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE : 30 mg/kg
SEX/DURATION : female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
NAGZAC Nagasaki Igakkai Zasshi. Journal of Nagasaki Medical Association.
(Nagasaki Igakkai, c/o Nagasaki Daigaku Igakubu, 12-4 Sakamoto-machi,
Nagasaki 852, Japan) V.1- 1923- Volume(issue)/page/year: 53,56,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE : 20 mg/kg
SEX/DURATION : female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
NAGZAC Nagasaki Igakkai Zasshi. Journal of Nagasaki Medical Association.
(Nagasaki Igakkai, c/o Nagasaki Daigaku Igakubu, 12-4 Sakamoto-machi,
Nagasaki 852, Japan) V.1- 1923- Volume(issue)/page/year: 53,45,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE : 40 mg/kg
SEX/DURATION : female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
REFERENCE :
NAGZAC Nagasaki Igakkai Zasshi. Journal of Nagasaki Medical Association.
(Nagasaki Igakkai, c/o Nagasaki Daigaku Igakubu, 12-4 Sakamoto-machi,
Nagasaki 852, Japan) V.1- 1923- Volume(issue)/page/year: 53,45,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE : 100 mg/kg
SEX/DURATION : female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
NAGZAC Nagasaki Igakkai Zasshi. Journal of Nagasaki Medical Association.
(Nagasaki Igakkai, c/o Nagasaki Daigaku Igakubu, 12-4 Sakamoto-machi,
Nagasaki 852, Japan) V.1- 1923- Volume(issue)/page/year: 53,45,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 100 mg/kg
SEX/DURATION : female 2 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
CGANE7 Congenital Anomalies. (Nippon Senten Ijo Gakkai, 377-2 Ono-higashi,
Osakasayama, Osaka-Fu 589 Japan) V.27- 1987- Volume(issue)/page/year:
36,83,1996
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 25 mg/kg
SEX/DURATION : female 2 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
CGANE7 Congenital Anomalies. (Nippon Senten Ijo Gakkai, 377-2 Ono-higashi,
Osakasayama, Osaka-Fu 589 Japan) V.27- 1987- Volume(issue)/page/year:
36,83,1996
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 50 mg/kg
SEX/DURATION : male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 17,77,1983
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 58500 ug/kg
SEX/DURATION : female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
34,151,1974
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 58500 ug/kg
SEX/DURATION : female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - body wall
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
34,151,1974
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 250 mg/kg
SEX/DURATION : male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc.,
41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year:
16,301,1996
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 75 mg/kg
SEX/DURATION : female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 92,193,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE : 351 mg/kg
SEX/DURATION : female 6-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes (including
somatic cell genetic material)
Reproductive - Effects on Newborn - germ cell effects (in offspring)
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc.,
41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year:
3,219,1983
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE : 80 mg/kg
SEX/DURATION : female 15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
EXPTAX Experimentelle Pathologie (1967-1980). (Jena, Ger. Dem. Rep.)
V.1-18, 1967-80. For publisher information, see EXPADD.
Volume(issue)/page/year: 15,105,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE : 80 mg/kg
SEX/DURATION : female 15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Effects on Newborn - delayed effects
REFERENCE :
NUPOBT Neuropatologia Polska. (Ars-Polona, POB 1001, 00-068 Warsaw 1,
Poland) V.1- 1963- Volume(issue)/page/year: 14,115,1976
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - mouse
DOSE : 80 mg/kg
SEX/DURATION : female 15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
43XWAI "Brain Tumors and Chemical Injuries to the Central Nervous System,
Proceedings of the International Neuropathological Symposium, Warsaw, 1976,"
Mossakowski, M.J., ed., Warsaw, Poland, Panstwowy Zaklad Wydawnictw
Lekarskich, 1978 Volume(issue)/page/year: -,30,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE : 30 mg/kg
SEX/DURATION : female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
PCBRD2 Progress in Clinical and Biological Research. (Alan R. Liss, Inc.,
41 E. 11th St., New York, NY 10003) V.1- 1975- Volume(issue)/page/year:
109,339,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rabbit
DOSE : 100 mg/kg
SEX/DURATION : female 18-27 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
Reproductive - Effects on Newborn - physical
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 65,607,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Mammal - pig
DOSE : 70 mg/kg
SEX/DURATION : female 14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 25,1606,1975
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - hamster
DOSE : 58565 ug/kg
SEX/DURATION : female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
29,1151,1969
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - hamster
DOSE : 58565 ug/kg
SEX/DURATION : female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
29,1151,1969
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 250 ug/plate
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 62,893,1979
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 100 ug/plate
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.1- 1915-
Volume(issue)/page/year: 72,5135,1975
TYPE OF TEST : Phage inhibition capacity
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 25 umol/L
REFERENCE :
MOPMA3 Molecular Pharmacology. (Williams & Wilkins Co., 428 E. Preston St.,
Baltimore, MD 21202) V.1- 1965- Volume(issue)/page/year: 10,640,1974
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 2600 umol/L/10M
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 43,11,1977
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 8 nmol/tube
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 147,79,1985
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 1 ug/well
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 46,53,1977
TYPE OF TEST : DNA damage
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 1800 umol/L
REFERENCE :
EJBCAI European Journal of Biochemistry. (Springer-Verlag New York, Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1967-
Volume(issue)/page/year: 56,433,1975
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 8 mmol/L
REFERENCE :
ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin,
Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see JCROD7.
Volume(issue)/page/year: 92,177,1978
TYPE OF TEST : Phage inhibition capacity
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 10 mg/L
REFERENCE :
APMBAY Applied Microbiology. (Washington, DC) V.1-30, 1953-75. For
publisher information, see AEMIDF. Volume(issue)/page/year: 23,91,1972
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Bacillus subtilis
DOSE/DURATION : 2 mg/disc
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 97,1,1982
TYPE OF TEST : DNA damage
TEST SYSTEM : Bacteria - Bacillus subtilis
DOSE/DURATION : 30 nmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
41,4368,1981
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 10 ng/disc
REFERENCE :
ISGEAK Issledovaniya po Genetike. (Izdatel'stvo Leningradskogo
Universiteta, Leningrad, USSR) No.1- 1961- Volume(issue)/page/year:
8,82,1979
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 1 pph
REFERENCE :
SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp.,
233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year:
7,948,1971
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 1200 ppm
REFERENCE :
MZHUDX Mikrobiologicheskii Zhurnal (Kiev). Journal of Microbiology. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.40- 1978-
Volume(issue)/page/year: 44(5),32,1982
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 100 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 7,1,1969
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 1500 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 16,265,1972
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 500 mg/L
REFERENCE :
DANND6 Dopovidi Akademii Nauk Ukrains'koi RSR, Seriya B: Geologichini,
Khimichni ta Biologichni Nauki. Transactions of the Academy of Sciences of
the Ukranian SSR, Series B. (V/O Mezhdunarodnaya Kniga, 113095, Moscow,
USSR) 1976- Volume(issue)/page/year: (9),70,1981
TYPE OF TEST : DNA damage
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 10 gm/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 2,363,1981
TYPE OF TEST : DNA damage
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 250 mg/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
13,151,1976
TYPE OF TEST : Phage inhibition capacity
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 100 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 36,265,1976
TYPE OF TEST : Specific locus test
ROUTE OF EXPOSURE : Inhalation
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 3 mg/L
REFERENCE :
GNKAA5 Genetika (Moscow). For English translation, see SOGEBZ. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1965-
Volume(issue)/page/year: 4(9),47,1968
TYPE OF TEST : Specific locus test
ROUTE OF EXPOSURE : Multiple routes
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 300 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 122,123,1983
TYPE OF TEST : Specific locus test
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 182,243,1987
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 30 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 6,483,1984
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Inhalation
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 16 mg/L/47H
REFERENCE :
SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp.,
233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year:
10,1172,1974
TYPE OF TEST : Dominant lethal test
ROUTE OF EXPOSURE : Inhalation
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 16 mg/L/47H
REFERENCE :
SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp.,
233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year:
10,1172,1974
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 800 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 253,103,1991
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Mold - Neurospora crassa
DOSE/DURATION : 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 125,43,1984
TYPE OF TEST : Gene conversion and mitotic recombination
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 4000 ppm
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 62,901,1979
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Protozoa - Chlamydomonas reinhardi
DOSE/DURATION : 5 mmol/L
REFERENCE :
FOMIAZ Folia Microbiologica (Prague). (Academia, Vodickova 40, 112 29
Prague 1, Czechoslavakia) V.4- 1959- Volume(issue)/page/year:
20,452,1975
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Protozoa - Euglena gracilis
DOSE/DURATION : 40 mg/L
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc.,
41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year:
5,329,1985
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Multiple routes
TEST SYSTEM : Non-mammalian species
DOSE/DURATION : 8500 nmol/L
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 4,17,1989
TYPE OF TEST : DNA damage
TEST SYSTEM : Fish - salmon Sperm
DOSE/DURATION : 2600 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 5,155,1984
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Insect - not otherwise specified Cells - not
otherwise specified
DOSE/DURATION : 25 mg/L
REFERENCE :
CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969-
Volume(issue)/page/year: 46,181,1986
TYPE OF TEST : DNA damage
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 1 mmol/L
REFERENCE :
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview
Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 6,149,1992
TYPE OF TEST : DNA damage
TEST SYSTEM : Human Liver
DOSE/DURATION : 1800 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
48,4144,1988
TYPE OF TEST : DNA damage
TEST SYSTEM : Human Fibroblast
DOSE/DURATION : 1500 ug/L
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
V.1- 1869- Volume(issue)/page/year: 276,85,1978
TYPE OF TEST : DNA damage
TEST SYSTEM : Human HeLa cell
DOSE/DURATION : 20 mg
REFERENCE :
BICHAW Biochemistry. (American Chemical Soc., Distribution Office Dept.
223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1962-
Volume(issue)/page/year: 14,1795,1975
TYPE OF TEST : DNA damage
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 1 mmol/L
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
Volume(issue)/page/year: 1(3),125,1982
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Human Liver
DOSE/DURATION : 320 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
48,4144,1988
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Human HeLa cell
DOSE/DURATION : 1 mmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
38,2621,1978
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 25 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
43,5846,1983
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 25 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
43,5846,1983
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 350 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
43,5846,1983
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Human HeLa cell
DOSE/DURATION : 100 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 92,427,1982
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Lung
DOSE/DURATION : 200 ug/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year:
41,37,1988
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Fibroblast
DOSE/DURATION : 100 umol/L/1H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 34,415,1976
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 25 mg/L
REFERENCE :
HUMAA7 Humangenetik. (Heidelberg, Fed. Rep. Ger.) V.1-30, 1964-75. For
publisher information, see HUGEDQ. Volume(issue)/page/year: 29,319,1975
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Lung
DOSE/DURATION : 10 ug/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year:
41,37,1988
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 200 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
48,3100,1988
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Fibroblast
DOSE/DURATION : 100 umol/L
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
V.1- 1869- Volume(issue)/page/year: 265,347,1977
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Human Fibroblast
DOSE/DURATION : 2 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 125,95,1984
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 100 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 160,95,1986
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 140 mg/kg
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 7,1053,1986
TYPE OF TEST : Morphological transformation
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 10 ng/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
43,709,1983
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - rat Embryo
DOSE/DURATION : 500 ug/L
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60,
1940-78. For publisher information, see JJIND8. Volume(issue)/page/year:
51,799,1973
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - rat Testis
DOSE/DURATION : 60 mg/L
REFERENCE :
CBTOE2 Cell Biology and Toxicology. (Princeton Scientific Pub., Inc., 301
N. Harrison St., CN 5279, Princeton, NJ 08540) V.1- 1984-
Volume(issue)/page/year: 1(3),181,1985
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 2 mmol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
46,165,1983
TYPE OF TEST : DNA damage
ROUTE OF EXPOSURE : Intravenous
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 29 mg/kg
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc.,
41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year:
7,175,1987
TYPE OF TEST : DNA damage
ROUTE OF EXPOSURE : Intravenous
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 500 umol/kg
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc.,
41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year:
9,157,1989
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - rat Fibroblast
DOSE/DURATION : 1700 umol/L
REFERENCE :
DABBBA Dissertation Abstracts International, B: The Sciences and
Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann
Arbor, MI 48106) V.30- 1969- Volume(issue)/page/year: 39,5889,1979
TYPE OF TEST : DNA damage
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 370 ug/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
47,3485,1987
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - rat Cells - not otherwise specified
DOSE/DURATION : 150 mg/L
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
V.1- 1869- Volume(issue)/page/year: 276,85,1978
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - rat Cells - not otherwise specified
DOSE/DURATION : 1 mmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
40,2898,1980
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - rat Sperm
DOSE/DURATION : 1 mmol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 6,273,1984
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - rat Cells - not otherwise specified
DOSE/DURATION : 1 mmol/L
REFERENCE :
PPTCBY Proceedings of the International Symposium of the Princess Takamatsu
Cancer Research Fund. (Japan Scientific Soc. Press, 6-2-10 Hongo, Bunkyo-ku,
Tokyo 113, Japan) 1st- 1971- Volume(issue)/page/year: 10,215,1980
TYPE OF TEST : Unscheduled DNA synthesis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 150 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 203,135,1988
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 320 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
48,4144,1988
TYPE OF TEST : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 100 mg/kg
REFERENCE :
ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin,
Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see JCROD7.
Volume(issue)/page/year: 79,255,1973
TYPE OF TEST : Body fluid assay
TEST SYSTEM : Rodent - rat Ovary
DOSE/DURATION : 75 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 143,263,1985
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 100 mg/kg
REFERENCE :
HUMAA7 Humangenetik. (Heidelberg, Fed. Rep. Ger.) V.1-30, 1964-75. For
publisher information, see HUGEDQ. Volume(issue)/page/year: 29,319,1975
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - rat Cells - not otherwise specified
DOSE/DURATION : 200 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
48,3100,1988
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - rat Cells - not otherwise specified
DOSE/DURATION : 100 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
43,473,1983
TYPE OF TEST : Mutation in mammalian somatic cells
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 100 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 263,257,1991
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 12500 ug/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 278,113,1992
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 25 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 223,377,1989
TYPE OF TEST : Specific locus test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 50 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 174,145,1986
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - mouse Embryo
DOSE/DURATION : 150 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52
Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year:
5,659,1985
TYPE OF TEST : Morphological transformation
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 25 mg/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
49,3620,1989
TYPE OF TEST : DNA damage
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 2 mmol/kg
REFERENCE :
33AQAA "Biology of Radiation Carcinogenesis, Symposium, 1975," Yuhas, J.M.,
et al., eds., New York, Raven Press, 1976 Volume(issue)/page/year:
-,165,1976
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 4990 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 203,155,1988
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION : 1 mmol/L
REFERENCE :
PPTCBY Proceedings of the International Symposium of the Princess Takamatsu
Cancer Research Fund. (Japan Scientific Soc. Press, 6-2-10 Hongo, Bunkyo-ku,
Tokyo 113, Japan) 1st- 1971- Volume(issue)/page/year: 10,215,1980
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION : 320 umol/L
REFERENCE :
PPTCBY Proceedings of the International Symposium of the Princess Takamatsu
Cancer Research Fund. (Japan Scientific Soc. Press, 6-2-10 Hongo, Bunkyo-ku,
Tokyo 113, Japan) 1st- 1971- Volume(issue)/page/year: 10,215,1980
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 63 mg/kg
REFERENCE :
PCBRD2 Progress in Clinical and Biological Research. (Alan R. Liss, Inc.,
41 E. 11th St., New York, NY 10003) V.1- 1975- Volume(issue)/page/year:
209B,477,1986
TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 70200 ug/kg
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 7(Suppl
3),30,1985
TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 17 mg/kg
REFERENCE :
CNJGA8 Canadian Journal of Genetics and Cytology. (National Research
Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6,
Canada) V.1- 1959- Volume(issue)/page/year: 28,286,1986
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 200 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 110,147,1983
TYPE OF TEST : Mutation in mammalian somatic cells
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 70200 ug/kg
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 7(Suppl
3),30,1985
TYPE OF TEST : Mutation in mammalian somatic cells
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 50 mg/kg
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
22,71,1993
TYPE OF TEST : Host-mediated assay
TEST SYSTEM : Rodent - mouse Bacteria - Salmonella typhimurium
DOSE/DURATION : 12 mg/kg
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 62,911,1979
TYPE OF TEST : Host-mediated assay
TEST SYSTEM : Rodent - mouse Bacteria - Escherichia coli
DOSE/DURATION : 190 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 272,161,1992
TYPE OF TEST : Heritable translocation test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 100 mg/kg
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
Switzerland) V.1- 1945- Volume(issue)/page/year: 44,253,1988
TYPE OF TEST : Morphological transformation
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - hamster
DOSE/DURATION : 200 mg/kg
REFERENCE :
ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50;
V.70-99, 1960-75. For publisher information, see APLMAS.
Volume(issue)/page/year: 95,380,1973
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - hamster Embryo
DOSE/DURATION : 500 ug/L
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966-
Volume(issue)/page/year: 19,642,1977
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - hamster Kidney
DOSE/DURATION : 250 ug/L
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 19,55,1981
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 300 umol/L/1H
REFERENCE :
BBRCA9 Biochemical and Biophysical Research Communications. (Academic
Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
Volume(issue)/page/year: 72,732,1976
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 5 mmol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
26,233,1979
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - hamster Cells - not otherwise specified
DOSE/DURATION : 1 mmol/L
REFERENCE :
PPTCBY Proceedings of the International Symposium of the Princess Takamatsu
Cancer Research Fund. (Japan Scientific Soc. Press, 6-2-10 Hongo, Bunkyo-ku,
Tokyo 113, Japan) 1st- 1971- Volume(issue)/page/year: 10,215,1980
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - hamster Cells - not otherwise specified
DOSE/DURATION : 320 umol/L
REFERENCE :
PPTCBY Proceedings of the International Symposium of the Princess Takamatsu
Cancer Research Fund. (Japan Scientific Soc. Press, 6-2-10 Hongo, Bunkyo-ku,
Tokyo 113, Japan) 1st- 1971- Volume(issue)/page/year: 10,215,1980
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - hamster
DOSE/DURATION : 100 mg/kg
REFERENCE :
TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo
Metropolitan Research Laboratory of Public Health. (Tokyo-toritsu Eisei
Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1-
1949/50- Volume(issue)/page/year: 36,396,1985
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Fibroblast
DOSE/DURATION : 125 mg/L/48H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 48,337,1977
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Lung
DOSE/DURATION : 200 ug/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year:
41,37,1988
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 684 umol/L
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 4,432,1989
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Embryo
DOSE/DURATION : 3 mmol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 6,1565,1985
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Lung
DOSE/DURATION : 10 ug/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year:
41,37,1988
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 1500 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 4,346,1982
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 20 umol/L/2H
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
26,233,1979
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 500 umol/L/1H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 111,341,1983
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - guinea pig Cells - not otherwise specified
DOSE/DURATION : 1 mmol/L
REFERENCE :
PPTCBY Proceedings of the International Symposium of the Princess Takamatsu
Cancer Research Fund. (Japan Scientific Soc. Press, 6-2-10 Hongo, Bunkyo-ku,
Tokyo 113, Japan) 1st- 1971- Volume(issue)/page/year: 10,215,1980
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - guinea pig Cells - not otherwise specified
DOSE/DURATION : 10 mmol/L
REFERENCE :
PPTCBY Proceedings of the International Symposium of the Princess Takamatsu
Cancer Research Fund. (Japan Scientific Soc. Press, 6-2-10 Hongo, Bunkyo-ku,
Tokyo 113, Japan) 1st- 1971- Volume(issue)/page/year: 10,215,1980
TYPE OF TEST : DNA adduct
TEST SYSTEM : Mammal - species unspecified Lymphocyte
DOSE/DURATION : 100 umol/L
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75,
1907-84. For publisher information, see JJCREP. Volume(issue)/page/year:
70,693,1979
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - rabbit Cells - not otherwise specified
DOSE/DURATION : 15 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 6,661,1985
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Mammal - species unspecified Lymphocyte
DOSE/DURATION : 1 mmol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
46,179,1983
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Mammal - pig Cells - not otherwise specified
DOSE/DURATION : 320 umol/L
REFERENCE :
PPTCBY Proceedings of the International Symposium of the Princess Takamatsu
Cancer Research Fund. (Japan Scientific Soc. Press, 6-2-10 Hongo, Bunkyo-ku,
Tokyo 113, Japan) 1st- 1971- Volume(issue)/page/year: 10,215,1980
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Mammal - pig Cells - not otherwise specified
DOSE/DURATION : 3200 umol/L
REFERENCE :
PPTCBY Proceedings of the International Symposium of the Princess Takamatsu
Cancer Research Fund. (Japan Scientific Soc. Press, 6-2-10 Hongo, Bunkyo-ku,
Tokyo 113, Japan) 1st- 1971- Volume(issue)/page/year: 10,215,1980
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Mammal - cattle Cells - not otherwise specified
DOSE/DURATION : 320 umol/L
REFERENCE :
PPTCBY Proceedings of the International Symposium of the Princess Takamatsu
Cancer Research Fund. (Japan Scientific Soc. Press, 6-2-10 Hongo, Bunkyo-ku,
Tokyo 113, Japan) 1st- 1971- Volume(issue)/page/year: 10,215,1980
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Mammal - cattle Cells - not otherwise specified
DOSE/DURATION : 3200 umol/L
REFERENCE :
PPTCBY Proceedings of the International Symposium of the Princess Takamatsu
Cancer Research Fund. (Japan Scientific Soc. Press, 6-2-10 Hongo, Bunkyo-ku,
Tokyo 113, Japan) 1st- 1971- Volume(issue)/page/year: 10,215,1980
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Subcutaneous
TEST SYSTEM : Primate - monkey
DOSE/DURATION : 500 umol/kg
REFERENCE :
FLNWAR Forschungsberichte des Landes Nordrhein-Westfalen. (Westdeutscher
Verlag GmbH, Postfach 300 620, 5090 Leverkusen 3, Fed. Rep. Ger.) 1960-
Volume(issue)/page/year: (3121),1,1982
*** REVIEWS ***
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 17,191,1978
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 17,191,1978
IARC Cancer Review:Group 2A
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987
TOXICOLOGY REVIEW
32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York,
Springer, 1975 Volume(issue)/page/year: -,49,1975
TOXICOLOGY REVIEW
INTEAG Internist. (Springer-Verlag New York, Inc., Service Center, 44 Hartz
Way, Secaucus, NJ 07094) V.1- 1960- Volume(issue)/page/year: 15,7,1974
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-FRANCE;Carcinogen JAN 1993
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: In vivo cytogenetics-nonhuman bone
marrow
EPA GENETOX PROGRAM 1988, Positive: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Positive: D melanogaster-partial sex chrom. loss
EPA GENETOX PROGRAM 1988, Positive: Host-mediated assay; Rodent heritable
translocation
EPA GENETOX PROGRAM 1988, Positive: Mouse spot test; N crassa-forward
mutation
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; Histidine
reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: In vitro SCE-human; Mouse specific locus
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: In vitro UDS-human fibroblast; UDS in
mouse germ cells
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S
cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro
cytogenetics-human lymphocyte
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Inconclusive: SHE-clonal assay
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-reciprocal
translocation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NTP 7th Annual Report on Carcinogens, 1992 : anticipated to be carcinogen
*** END OF RECORD ***