*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YT4400000
CHEMICAL NAME           : Urea,
                          1-(hexahydro-1H-azepin-1-yl)-3-(p-tolylsulfonyl)-
CAS REGISTRY NUMBER     : 1156-19-0
BEILSTEIN REFERENCE NO. : 1323565
REFERENCE               : 5-20-04-00062 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C14-H21-N3-O3-S
MOLECULAR WEIGHT        : 311.44
WISWESSER LINE NOTATION : T7NTJ AMVMSWR D1
COMPOUND DESCRIPTOR     : Tumorigen
                          Drug
                          Mutagen
                          Human
SYNONYMS/TRADE NAMES :
   * Benzenesulfonamide,  
   N-(((hexahydro-1H-azepin-1-yl)-amino)carbonyl)-4-methyl-
   * 1-(Hexahydro-1-azepinyl)-3-p-tolylsulfonylurea
   * 1-(Hexahydro-1H-azepin-1-yl)-3-(p-tolylsulfonyl)urea
   * NSC-70762
   * NCI-C03327
   * Tolazamide
   * Tolinase
   * N-(p-Toluenesulfonyl)-N'-hexamethyleniminourea
   * 4-(p-Tolylsulfonyl)-1,1-hexamethylenesemicarbazide
   * U 17835
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 256 mg/kg/3W-I
TOXIC EFFECTS :
   Liver - jaundice, other or unclassified
   Liver - liver function tests impaired
REFERENCE :
   GASTAB Gastroenterology.  (Academic Press, Inc., 1 E. First St., Duluth, MN
   55802)  V.1-    1943-  Volume(issue)/page/year: 89,192,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,511,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 24,1521,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 24,1521,1981
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 4 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 368,59,1996

                          *** STATUS IN U.S. ***
 
   NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-51,78

 
                            *** END OF RECORD ***