*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YT7175000
CHEMICAL NAME           : Urea, methyl-
CAS REGISTRY NUMBER     : 598-50-5
LAST UPDATED            : 199710
DATA ITEMS CITED        : 10
MOLECULAR FORMULA       : C2-H6-N2-O
MOLECULAR WEIGHT        : 74.10
WISWESSER LINE NOTATION : ZVM1
COMPOUND DESCRIPTOR     : Agricultural Chemical
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Methylharnstoff
   * Methylmocovina
   * Methylurea
   * N-Methylurea
   * 1-Methylurea
   * Monomethylurea
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCNSA6 National Academy of Sciences, National Research Council,
   Chemical-Biological Coordination Center, Review.  (Washington, DC)
   Volume(issue)/page/year: 5,47,1953
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APEPA2 Naunyn-Schmiedebergs Archiv fuer Pharmakologie und Experimentelle
   Pathologie.  (Berlin, Ger.) V.254-263, 1966-69.  For publisher information,
   see NSAPCC.  Volume(issue)/page/year: 257,296,1967
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 10189 mg/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 52,216,1934
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 5 gm/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 42,19,1977
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 500 ppm/1H
REFERENCE :
   SOGEBZ Soviet Genetics.  English translation of GNKAA5.  (Plenum Pub. Corp.,
   233 Spring St., New York, NY 10013)  V.2-    1966- Volume(issue)/page/year:
   12,772,1976
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Protozoa - Chlamydomonas reinhardi
DOSE/DURATION           : 400 mmol/L
REFERENCE :
   FOMIAZ Folia Microbiologica (Prague).  (Academia, Vodickova 40, 112 29
   Prague 1, Czechoslavakia) V.4-    1959-  Volume(issue)/page/year:
   20,452,1975

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: Host-mediated assay
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***