*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YV9365000
CHEMICAL NAME           : Valine,
                          N-(N-acetyl-3-(p-(bis(2-chloroethyl)amino)phenyl)alan
                          yl)-, ethyl ester
CAS REGISTRY NUMBER     : 13425-94-0
LAST UPDATED            : 199706
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C22-H33-Cl2-N3-O4
MOLECULAR WEIGHT        : 474.48
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * N-Acetyl-sarcolysil valine ethyl ether
   * Asalin
   * Asaline
   * Ethyl ester of N-acetyl-DL-sarcolysyl-DL-valine
   * Valine, N-(N-acetyl-4-(bis(2-chloroethyl)amino)phenylalanyl)-, ethyl  
   ester
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 187 mg/kg
TOXIC EFFECTS :
   Blood - leukopenia
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 12,25,1978
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 590 mg/kg/10D-I
TOXIC EFFECTS :
   Related to Chronic Data - death
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 33,472,1970
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 165 mg/kg/10D-I
TOXIC EFFECTS :
   Related to Chronic Data - death
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 33,472,1970
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Rectal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 400 mg/kg/10D-I
TOXIC EFFECTS :
   Related to Chronic Data - death
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 33,472,1970
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 50 mg/kg
SEX/DURATION            : female 6 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
   VOONAW Voprosy Onkologii.  Problems of Oncology.  For English translation,
   see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-10,
   1928-37; V.1-    1955-  Volume(issue)/page/year: 13(11),79,1967
 
                            *** END OF RECORD ***