*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YX3973800
CHEMICAL NAME           : Venom, snake, Bitis nasicornis
LAST UPDATED            : 199109
DATA ITEMS CITED        : 5
COMPOUND DESCRIPTOR     : Natural Product
SYNONYMS/TRADE NAMES :
   * Bitis nasicornis shaw venom
   * Bitis nasicornis venom
   * Horned viper venom
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3200 ug/kg
TOXIC EFFECTS :
   Cardiac - pulse rate
REFERENCE :
   TOXIA6 Toxicon.  (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
   UK)  V.1-    1962-  Volume(issue)/page/year: 23,567,1985
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 18500 ug/kg
TOXIC EFFECTS :
   Blood - hemorrhage
REFERENCE :
   TOXIA6 Toxicon.  (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
   UK)  V.1-    1962-  Volume(issue)/page/year: 12,621,1974
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1056 ug/kg
TOXIC EFFECTS :
   Blood - hemorrhage
   Blood - change in clotting factors
REFERENCE :
   23EIAT "Venomous Animals and Their Venoms," Buecherl, W., and E.E. Buckley,
   eds., 3 vols., New York, Academic Press, Inc., 1968-71
   Volume(issue)/page/year: 1,437,1968
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 8600 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOXIA6 Toxicon.  (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
   UK)  V.1-    1962-  Volume(issue)/page/year: 6,175,1969
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 375 ug/kg
TOXIC EFFECTS :
   Vascular - BP lowering not characterized in autonomic section
   Lungs, Thorax, or Respiration - dyspnea
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   TOXIA6 Toxicon.  (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
   UK)  V.1-    1962-  Volume(issue)/page/year: 12,621,1974
 
                            *** END OF RECORD ***