*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : YX3985900
CHEMICAL NAME : Venom, snake, Enhydrina schistosa
LAST UPDATED : 199109
DATA ITEMS CITED : 15
COMPOUND DESCRIPTOR : Natural Product
SYNONYMS/TRADE NAMES :
* Australian beaked sea snake
* Enhydrina schistosa venom
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 70 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TRSTAZ Transactions of the Royal Society of Tropical Medicine and Hygiene.
(Royal Soc. of Tropical Medicine and Hygiene, Manson House, 26 Portland Pl.,
London W1N 4EY, UK) V.14- 1920- Volume(issue)/page/year: 54,50,1960
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 250 ug/kg
TOXIC EFFECTS :
Blood - change in clotting factors
REFERENCE :
23EIAT "Venomous Animals and Their Venoms," Buecherl, W., and E.E. Buckley,
eds., 3 vols., New York, Academic Press, Inc., 1968-71
Volume(issue)/page/year: 1,285,1968
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 100 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - muscle weakness
REFERENCE :
AJEBAK Australian Journal of Experimental Biology and Medical Science.
(Adelaide, S.A., Australia) V.1-64, 1924-86. Volume(issue)/page/year:
40,427,1962
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 111 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
UK) V.1- 1962- Volume(issue)/page/year: 14,347,1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 74 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
UK) V.1- 1962- Volume(issue)/page/year: 20,797,1982
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 125 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SCNEBK Science News. (Science Service, Subscription Dept., 231 W. Center
St., Marion, OH 43302) V.89(11)- 1966- Volume(issue)/page/year:
110,355,1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 57 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TRSTAZ Transactions of the Royal Society of Tropical Medicine and Hygiene.
(Royal Soc. of Tropical Medicine and Hygiene, Manson House, 26 Portland Pl.,
London W1N 4EY, UK) V.14- 1920- Volume(issue)/page/year: 54,50,1960
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 28500 ng/kg
TOXIC EFFECTS :
Blood - change in clotting factors
REFERENCE :
23EIAT "Venomous Animals and Their Venoms," Buecherl, W., and E.E. Buckley,
eds., 3 vols., New York, Academic Press, Inc., 1968-71
Volume(issue)/page/year: 1,285,1968
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 61 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TRSTAZ Transactions of the Royal Society of Tropical Medicine and Hygiene.
(Royal Soc. of Tropical Medicine and Hygiene, Manson House, 26 Portland Pl.,
London W1N 4EY, UK) V.14- 1920- Volume(issue)/page/year: 54,50,1960
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 122 ug/kg
TOXIC EFFECTS :
Blood - change in clotting factors
REFERENCE :
23EIAT "Venomous Animals and Their Venoms," Buecherl, W., and E.E. Buckley,
eds., 3 vols., New York, Academic Press, Inc., 1968-71
Volume(issue)/page/year: 1,285,1968
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Amphibian - frog
DOSE/DURATION : 20 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TRSTAZ Transactions of the Royal Society of Tropical Medicine and Hygiene.
(Royal Soc. of Tropical Medicine and Hygiene, Manson House, 26 Portland Pl.,
London W1N 4EY, UK) V.14- 1920- Volume(issue)/page/year: 54,50,1960
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Amphibian - frog
DOSE/DURATION : 606 ug/kg
TOXIC EFFECTS :
Blood - change in clotting factors
REFERENCE :
23EIAT "Venomous Animals and Their Venoms," Buecherl, W., and E.E. Buckley,
eds., 3 vols., New York, Academic Press, Inc., 1968-71
Volume(issue)/page/year: 1,285,1968
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 10 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLPTAT Clinical Pharmacology and Therapeutics (St. Louis). (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1960-
Volume(issue)/page/year: 8,849,1967
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 50 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
V.1- 1869- Volume(issue)/page/year: 185,103,1960
*** REVIEWS ***
TOXICOLOGY REVIEW
KOBUA3 Kobunshi. High Polymers. (Kobunshi Gakkai, 5-12-8, Ginza, Chuo-Ku,
Tokyo 104, Japan) V.1- 1952- Volume(issue)/page/year: 23,728,1974
*** END OF RECORD ***