*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YX7140000
CHEMICAL NAME           : Veratrum californicum
SUBSTANCE DEFINITION :
   Top (plant) material from Veratrum californicum (durand)
REFERENCE :
   CJBIAE Canadian Journal of Biochemistry.  (Ontario, Canada)  V.42-60,
   1964-82.  For publisher information, see CJBBDU.
LAST UPDATED            : 199506
DATA ITEMS CITED        : 4
COMPOUND DESCRIPTOR     : Reproductive Effector
                          Natural Product
SYNONYMS/TRADE NAMES :
   * False hellebore
   * Skunk cabbage
   * Western hellebore
   * Wild corn
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 900 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Lungs, Thorax, or Respiration - dyspnea
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   AFECAT Annales des Falsifications et de l'Expertise Chimique.  (Paris,
   France)  V.53, No.613-No.779, 1960-79.  Volume(issue)/page/year:
   76(815),65,1983
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 15 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMZOAF American Zoologist.  (American Soc. of Zoologists, Box 2739,
   California Lutheran College, Thousand Oaks, CA 91360)  V.1-    1961-
   Volume(issue)/page/year: 9,1134,1969
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - domestic
DOSE                    : 236 gm/kg
SEX/DURATION            : female 1-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
   AJVRAH American Journal of Veterinary Research.  (American Veterinary
   Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196)  V.1-    1940-
   Volume(issue)/page/year: 24,1164,1963

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   AEMBAP Advances in Experimental Medicine and Biology.  (Plenum Pub. Corp.,
   233 Spring St., New York, NY 10013)  V.1-    1967- Volume(issue)/page/year:
   27,107,1972

 
                            *** END OF RECORD ***