*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YY8150000
CHEMICAL NAME           : Vincaleukoblastine, deacetyl-
CAS REGISTRY NUMBER     : 3352-69-0
LAST UPDATED            : 199309
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C44-H55-N4-O8
MOLECULAR WEIGHT        : 768.03
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Deacetylvinblastine
   * 4-Deacetylvinblastine
   * Desacetylvinblastine
   * Vincaleukoblastine, O(sup 4)-deacetyl-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5900 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   26,1213,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5800 ug/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 21,88,1978
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5120 ug/kg/4W-I
TOXIC EFFECTS :
   Endocrine - other changes
   Blood - changes in leukocyte (WBC) count
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   17,482,1991
 
                            *** END OF RECORD ***