*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YY8575000
CHEMICAL NAME           : Vincamine
CAS REGISTRY NUMBER     : 1617-90-9
LAST UPDATED            : 199706
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C21-H26-N2-O3
MOLECULAR WEIGHT        : 354.49
WISWESSER LINE NOTATION : T D6 B5666 2AB S CN MN&&TTTJ Q2 SVO1 SQ
COMPOUND DESCRIPTOR     : Drug
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Anasclerol
   * Angiopac
   * Arteriovinca
   * Decincan
   * Devincan
   * Devinkan
   * 14,15-Dihydro-14-hydroxyeburnamenine-14-carboxylic acid methyl ester
   * Eburnamenine-14-carboxylic acid, 14,15-dihydro-14-hydroxy-, methyl ester, 
    (3alpha,14beta,16.)
   * Equipur
   * Methyl vincaminate
   * Minorin
   * Minorine
   * Novicet
   * Ocu-vinc
   * Oxygeron
   * Perval
   * Pervincamine
   * Pervone
   * Tripervan
   * Vincadar
   * Vincafolina
   * Vincafor
   * Vincagil
   * Vincamidol
   * (+)-Vincamine
   * cis-Vincamine
   * (+)-cis-Vincamine
   * Vincapan
   * Vincapront
   * Vincasaunier
   * Vincimax
   * Vinodrel retard
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #3852453
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 253 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 32,601,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 460 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4011330
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 195 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EPXXDW European Patent Application. (U.S. Patent and Trademark Office,
   Foreign Patents, Washington, DC 20231)  Volume(issue)/page/year: #0052238
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 47740 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AGSOA6 Agressologie.  Revue Internationale de Physio-Biologie et de
   Pharmacologie Appliquees aux Effets de l'Agression.  (SPPIF, B.P.22, F-41353
   Vineuil, France)  V.1-    1960-  Volume(issue)/page/year: 19,211,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 33 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 236,296,1959
 
                            *** END OF RECORD ***