*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YY8575570
CHEMICAL NAME           : Vincamone
CAS REGISTRY NUMBER     : 4880-88-0
LAST UPDATED            : 199703
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C19-H22-N2-O
MOLECULAR WEIGHT        : 294.43
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * CH-846
   * Eburnal
   * Eburnal ritardo
   * Eburnamin-14(15H)-one, (3-alpha,16-alpha)-
   * (-)-Eburnamonina
   * (-)-Eburnamonine
   * 3-alpha,16-alpha-Eburnamonine
   * l-Eburnamonine
   * Vincamona
   * cis-Vincamone
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #3852453
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 265 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   MDACAP Medicamentos de Actualidad.  (J.R. Prous, S.A., Apartado de Correos
   540, 08080 Barcelona, Spain)  V.1-    1965-  Volume(issue)/page/year:
   14,160,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 28 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   MDACAP Medicamentos de Actualidad.  (J.R. Prous, S.A., Apartado de Correos
   540, 08080 Barcelona, Spain)  V.1-    1965-  Volume(issue)/page/year:
   14,160,1978
 
                            *** END OF RECORD ***