*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : YY8575570 CHEMICAL NAME : Vincamone CAS REGISTRY NUMBER : 4880-88-0 LAST UPDATED : 199703 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C19-H22-N2-O MOLECULAR WEIGHT : 294.43 COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * CH-846 * Eburnal * Eburnal ritardo * Eburnamin-14(15H)-one, (3-alpha,16-alpha)- * (-)-Eburnamonina * (-)-Eburnamonine * 3-alpha,16-alpha-Eburnamonine * l-Eburnamonine * Vincamona * cis-Vincamone *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3852453 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 265 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands REFERENCE : MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 14,160,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 28 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands REFERENCE : MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 14,160,1978 *** END OF RECORD ***