*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : ZB1635000
CHEMICAL NAME : Vobasan-17-oic acid, 19,20-dihydro-3-oxo-, methyl
ester, (20-alpha)-
CAS REGISTRY NUMBER : 2299-26-5
LAST UPDATED : 199706
DATA ITEMS CITED : 3
MOLECULAR FORMULA : C21-H26-N2-O3
MOLECULAR WEIGHT : 354.49
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* (20-alpha)-19,20-Dihydro-3-oxovobasan-17-oic acid methyl ester
* Dregamine
* (-)-Dregamine
* 20-Epitabernemontanine
* Methyl (20-alpha)-19,20-dihydro-3-oxovobasan-17-oate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 130 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil,
France) V.1- 1943- Volume(issue)/page/year: 28,697,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 52 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - rigidity (including catalepsy)
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil,
France) V.1- 1943- Volume(issue)/page/year: 28,697,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 24 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil,
France) V.1- 1943- Volume(issue)/page/year: 28,697,1970
*** END OF RECORD ***