*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : ZD8500000
CHEMICAL NAME           : Xanthine, 3-isobutyl-1-methyl-
CAS REGISTRY NUMBER     : 28822-58-4
LAST UPDATED            : 199706
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C10-H14-N4-O2
MOLECULAR WEIGHT        : 222.28
WISWESSER LINE NOTATION : T56 BM DN FNVNVJ F1Y1&1 H1
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * IBMX
   * 3-Isobutyl-1-methylxanthine
   * 1H-Purine-2,6-dione, 3,7-dihydro-1-methyl-3-(2-methylpropyl)-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 44 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
   (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
   V.9-    1974-  Volume(issue)/page/year: 25,653,1990
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   BIOJAU Biophysical Journal.  (Rockefeller Univ. Press, 1230 York Ave., New
   York, NY 10021) V.1-    1960-  Volume(issue)/page/year: 35,665,1981
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 4 mmol/L
REFERENCE :
   BIOJAU Biophysical Journal.  (Rockefeller Univ. Press, 1230 York Ave., New
   York, NY 10021) V.1-    1960-  Volume(issue)/page/year: 35,665,1981
 
TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Cells - not otherwise specified
DOSE/DURATION           : 100 umol/L
REFERENCE :
   ABMGAJ Acta Biologica et Medica Germanica.  (Berlin, Ger. Dem. Rep.) V.1-41,
   1958-82.  For publisher information, see BBIADT. Volume(issue)/page/year:
   41,1171,1982
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Embryo
DOSE/DURATION           : 1500 umol/L
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 31,155,1985
 
TYPE OF TEST            : DNA inhibition
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 20 mg/kg
REFERENCE :
   RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
   Pub. Ltd., P.O. Box 966, Westbury, NY 11590)  V.1-    1970-
   Volume(issue)/page/year: 54,121,1986

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X6639
       No. of Facilities: 3 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 198 (estimated)
       No. of Female Employees: 151 (estimated)

 
                            *** END OF RECORD ***