*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : ZE6850000 CHEMICAL NAME : 3,5-Xylenol, 4-chloro- CAS REGISTRY NUMBER : 88-04-0 BEILSTEIN REFERENCE NO. : 1862539 REFERENCE : 4-06-00-03152 (Beilstein Handbook Reference) LAST UPDATED : 199701 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C8-H9-Cl-O MOLECULAR WEIGHT : 156.62 WISWESSER LINE NOTATION : QR DG C1 E1 COMPOUND DESCRIPTOR : Mutagen Reproductive Effector Primary Irritant SYNONYMS/TRADE NAMES : * Benzytol * 4-Chloro-3,5-dimethylphenol * 2-Chloro-5-hydroxy-1,3-dimethylbenzene * 4-Chloro-1-hydroxy-3,5-dimethylbenzene * 2-Chloro-5-hydroxy-m-xylene * Chloro-xylenol * p-Chloro-m-xylenol * 2-Chloro-m-xylenol * 4-Chloro-3,5-xylenol * Desson * Dettol * Espadol * Husept Extra * Nipacide MX * Ottasept * Ottasept Extra * PCMX * Phenol, 4-chloro-3,5-dimethyl- * RBA 777 *** HEALTH HAZARD DATA *** ** SKIN/EYE IRRITATION DATA ** TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration into the eye SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 100 mg REACTION SEVERITY : Moderate REFERENCE : JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 4(5),147,1985 ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3830 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - other changes Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes REFERENCE : JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 4(5),147,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Gastrointestinal - other changes REFERENCE : SRTCAC Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. (Tohoku University, Research Institute for Tuberculosis and Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949- Volume(issue)/page/year: 36(1-4),10,1989 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 115 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 41,595,1952 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 17100 mg/kg SEX/DURATION : female 1-19 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : AOISDR Annual Report of Osaka City Institute of Public Health and Environmental Sciences. (Osaka- shiritsu Kankyo Kagaku Kenkyusho, 8-34 Tojo-cho, Tennoji-ku, Osaka 543, Japan) No.42- 1981- Volume(issue)/page/year: (45),100,1983 ** MUTATION DATA ** TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 100 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 307,141,1994 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80083 No. of Facilities: 10592 (estimated) No. of Industries: 94 No. of Occupations: 137 No. of Employees: 441808 (estimated) No. of Female Employees: 223953 (estimated) *** STATUS IN U.S. *** EPA TSCA Section 8(b) CHEMICAL INVENTORY *** END OF RECORD ***