*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YX4004500
CHEMICAL NAME           : Venom, spider, Phoneutria nigriventer
LAST UPDATED            : 199206
DATA ITEMS CITED        : 5
COMPOUND DESCRIPTOR     : Natural Product
SYNONYMS/TRADE NAMES :
   * Phoneutria nigriventer venom
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 670 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SCNEBK Science News.  (Science Service, Subscription Dept., 231 W. Center
   St., Marion, OH 43302) V.89(11)-    1966-  Volume(issue)/page/year:
   110,355,1976
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 300 ug/kg
TOXIC EFFECTS :
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   23EIAT "Venomous Animals and Their Venoms," Buecherl, W., and E.E. Buckley,
   eds., 3 vols., New York, Academic Press, Inc., 1968-71
   Volume(issue)/page/year: 3,197,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 47 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOXIA6 Toxicon.  (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
   UK)  V.1-    1962-  Volume(issue)/page/year: 29,1225,1991
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 760 ug/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - altered sleep time (including change in righting reflex)
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   23EIAT "Venomous Animals and Their Venoms," Buecherl, W., and E.E. Buckley,
   eds., 3 vols., New York, Academic Press, Inc., 1968-71
   Volume(issue)/page/year: 3,279,1971
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 180 ug/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - muscle weakness
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   23EIAT "Venomous Animals and Their Venoms," Buecherl, W., and E.E. Buckley,
   eds., 3 vols., New York, Academic Press, Inc., 1968-71
   Volume(issue)/page/year: 3,279,1971
 
                            *** END OF RECORD ***