*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : ZG1035000
CHEMICAL NAME           : 20-alpha-Yohimban-16-beta-carboxylic acid,
                          17-alpha-hydroxy-, methyl ester, hydrochloride
CAS REGISTRY NUMBER     : 6211-32-1
LAST UPDATED            : 199203
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C21-H26-N2-O3.Cl-H
MOLECULAR WEIGHT        : 390.95
WISWESSER LINE NOTATION : T F6 D5 C666 EM ON&&TTTJ TQ UVO1 &GH
SYNONYMS/TRADE NAMES :
   * Rauwolscine hydrochloride
   * alpha-Yohimbine hydrochloride
   * alpha-Yohimbin hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 125 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   LDBU** "Zur Pharmakologie der Yohimbealkaloide, Dissertation," Langer, J.,
   Institute fuer Pharmakologie und Experimentelle Therapie der Universitat
   Breslau, Poland, 1932  Volume(issue)/page/year: -,-,1932
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   LDBU** "Zur Pharmakologie der Yohimbealkaloide, Dissertation," Langer, J.,
   Institute fuer Pharmakologie und Experimentelle Therapie der Universitat
   Breslau, Poland, 1932  Volume(issue)/page/year: -,-,1932
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   LDBU** "Zur Pharmakologie der Yohimbealkaloide, Dissertation," Langer, J.,
   Institute fuer Pharmakologie und Experimentelle Therapie der Universitat
   Breslau, Poland, 1932  Volume(issue)/page/year: -,-,1932
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 162 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BSPHAV Bulletin des Sciences Pharmacologiques.  (Paris, France)  V.1-49,
   1899-1942.  For publisher information, see APFRAD. Volume(issue)/page/year:
   47,33,1940
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BSPHAV Bulletin des Sciences Pharmacologiques.  (Paris, France)  V.1-49,
   1899-1942.  For publisher information, see APFRAD. Volume(issue)/page/year:
   47,33,1940
 
                            *** END OF RECORD ***