*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : ZI2300000
CHEMICAL NAME           : Zorbamycin, hydrochloride
CAS REGISTRY NUMBER     : 11056-20-5
LAST UPDATED            : 199709
DATA ITEMS CITED        : 30
MOLECULAR FORMULA       : C56-H100-N18-O24-S2.Cu.2Cl-H
MOLECULAR WEIGHT        : 1610.32
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Antibiotic 241D dihydrochloride
   * 241D dihydrochloride
   * NSC 146208
   * U-30604E
   * Zorbamycin
   * Zorbamycin dihydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 22 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   UPJOH* "Compounds Available for Fundamental Research, Volume II-6,
   Antibiotics, A Program of Upjohn Company Research Laboratory."  (Kalamazoo,
   MI 49001)  Volume(issue)/page/year: 2(6),-,1971
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 100 ng/plate
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   43,2819,1983

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-ARAB Republic of Egypt:TWA 0.1 mg(Cu)/m3 (fume) JAN 1993
   
   OEL-AUSTRALIA:TWA 0.2 mg(Cu)/m3 (fume) JAN 1993
   
   OEL-AUSTRALIA:TWA 1 mg(Cu)/m3 (dust) JAN 1993
   
   OEL-BELGIUM:TWA 0.2 mg(Cu)/m3 (fume) JAN 1993
   
   OEL-BELGIUM:TWA 1 mg(Cu)/m3 (dust) JAN 1993
   
   OEL-DENMARK:TWA 0.1 mg(Cu)/m3 (fume) JAN 1993
   
   OEL-DENMARK:TWA 1 mg(Cu)/m3 (dust) JAN 1993
   
   OEL-FINLAND:TWA 0.2 mg(Cu)/m3 (fume) JAN 1993
   
   OEL-FINLAND:TWA 1 mg(Cu)/m3 (dust) JAN 1993
   
   OEL-FRANCE:TWA 0.2 mg(Cu)/m3 (fume) JAN 1993
   
   OEL-FRANCE:TWA 1 mg(Cu)/m3;STEL 2 mg(Cu)/m3 (dust) JAN 1993
   
   OEL-GERMANY:TWA 0.1 mg(Cu)/m3 (fume) JAN 1993
   
   OEL-GERMAY:TWA 1 mg(Cu)/m3 (dust) JAN 1993
   
   OEL-HUNGARY:TWA 0.2 mg(Cu)/m3;STEL 0.4 mg(Cu)/m3 (dust) JAN 1993
   
   OEL-INDIA:TWA 0.2 mg(Cu)/m3 (fume) JAN 1993
   
   OEL-THE NETHERLANDS:TWA 02 mg(Cu)/m3 (fume) JAN 1993
   
   OEL-THE NETHERLANDS:TWA 1 mg(Cu)/m3 (dust) JAN 1993
   
   OEL-THE PHILIPPINES:TWA 1.0 mg(Cu)/m3 (fume) JAN 1993
   
   OEL-POLAND:TWA 0.1 mg(Cu)/m3 (fume) JAN 1993
   
   OEL-RUSSIA:STEL 0.5 ppm (1 mg(Cu)/m3) (dust) JAN 1993
   
   OEL-SWEDEN:TWA 0.2 mg(Cu)/m3 (resp. dust) JAN 1993
   
   OEL-SWEDEN:TWA 0.2 mg(Cu)/m3 (fume) JAN 1993
   
   OEL-SWEDEN:TWA 1 mg(Cu)/m3 (total dust) JAN 1993
   
   OEL-SWITZERLAND:TWA 0.1 mg(Cu)/m3;STEL 0.2 mg(Cu)/m3 (fume) JAN 1993
   
   OEL-SWITZERLAND:TWA 1 mg(Cu)/m3;STEL 1 mg(Cu)/m3 JAN 1993
   
   OEL-THAILAND:TWA 0.1 mg(Cu)/m3 (fume) JAN 1993
   
   OEL-THAILAND:TWA 1 mg(Cu)/m3 JAN 1993
   
   OEL-UNITED KINGDOM:TWA 0.2 mg(Cu)/m3 (fume) JAN 1993

 
                            *** END OF RECORD ***