*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CN0739000
CHEMICAL NAME           : Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione,
                          1,1a,2,8,8a,8b-hexahydro-6-
                          (((dimethylamino)methylene)amino)-8-(hydroxymethyl)-8
                          a-methoxy-5-methyl-, carbamate (ester)
CAS REGISTRY NUMBER     : 88949-01-3
LAST UPDATED            : 199309
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C18-H23-N5-O5
MOLECULAR WEIGHT        : 389.46
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * BMY-25282
   * 7-N-(Dimethylaminomethylene)mitomycin C
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 250 ug/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - dyspnea
   Skin and Appendages - hair
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   9,90,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2100 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   45,6475,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1400 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   45,6475,1985
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 250 ug/kg/5D-I
TOXIC EFFECTS :
   Cardiac - cardiomyopathy including infarction
   Kidney, Ureter, Bladder - changes in both tubules and glomeruli
   Related to Chronic Data - death
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   9,90,1987
 
                            *** END OF RECORD ***