*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CO9550000
CHEMICAL NAME           : Bacillus subtilis carlsberg
CAS REGISTRY NUMBER     : 9014-01-1
LAST UPDATED            : 199712
DATA ITEMS CITED        : 14
COMPOUND DESCRIPTOR     : Primary Irritant
SYNONYMS/TRADE NAMES :
   * Alcalase
   * ALK-enzyme
   * Bacillopeptidase A
   * Bacillopeptidase B
   * Bioprase
   * Colistinase
   * E.C. 3.4.4.16
   * E.C. 3.4.21.14
   * Maxatase
   * Nagarse
   * SP 266
   * Subtilisin
   * Subtilisin
   * Subtilisin bpn'
   * Subtilisin carlsburg
   * Subtilisin NOVO
   * Subtilopeptidase A
   * Subtilopeptidase B
   * Subtilopeptidase bpn'
   * Subtilopeptidase C
   * Thermoase PC-10
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration into the eye
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 3 mg
REACTION SEVERITY       : Moderate
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 7,581,1969
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 7,581,1969

                              *** REVIEWS ***
 
   ACGIH TLV-CL 0.00006 mg/m3, high-volume sampling
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   TLV/BEI,1997

                    *** U.S. STANDARDS AND REGULATIONS ***
 
   MSHA STANDARD-air:TWA 0.0003 mg/m3
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   3,236,1971

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-DENMARK:TWA 0.00006 mg/m3 JAN 1993
   
   OEL-THE NETHERLANDS:TWA 0.00006 mg/m3 JAN 1993
   
   OEL-UNITED KINGDOM:TWA 0.00006 mg/m3;STEL 0.00006 mg/m3 JAN 1993
   
   OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
   
   OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
   NIOSH REL TO SUBTILISINS-air:STEL 0.00006 mg/m3/60M
REFERENCE :
   NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
   Health, Education, and Welfare, Reports and Memoranda.
   Volume(issue)/page/year: DHHS #92-100,1992

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X1796
       No. of Facilities: 225 (estimated)
       No. of Industries: 3
       No. of Occupations: 5
       No. of Employees: 5548 (estimated)
       No. of Female Employees: 1814 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8800
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***