*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CP8400000
CHEMICAL NAME           : Barbituric acid,
                          5-allyl-5-(2-cyclohexen-1-yl)-2-thio-
CAS REGISTRY NUMBER     : 467-36-7
LAST UPDATED            : 199007
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C13-H16-N2-O2-S
MOLECULAR WEIGHT        : 264.37
WISWESSER LINE NOTATION : T6VMYMV FHJ CUS F2U1 F- CL6UTJ
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 5-Allyl-5-(2-cyclohexen-1-yl)-2-thiobarbituric acid
   * 5-delta(sup 2:3)-Cyclohexenyl-5-allyl-2-thiobarbituric acid
   * Kemithal
   * 4,6(1H,5H)-Pyrimidinedione,  
   5-(2-cyclohexen-1-yl)dihydro-5-(2-propenyl)-2-thioxo-
   * Thialbarbital
   * Thialbarbitone
   * Thialpenton
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 175 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 106,437,1956
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 370 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 1,215,1946
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 384 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 1,215,1946
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 240 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FSTEAI Farmaco. Scienza e Tecnica.  (Pavia, Italy)  V.1-7, 1946-52.  For
   publisher information, see FRPSAX.  Volume(issue)/page/year: 3,269,1948
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 390 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 1,215,1946
 
                            *** END OF RECORD ***