*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CN1053000
CHEMICAL NAME           : Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione,
                          1,1a,2,8,8a,8b-hexahydro-8-
                          (hydroxymethyl)-6-(p-hydroxyanilino)-8a-methoxy-5-met
                          hyl-, 8-carbamate (ester)
CAS REGISTRY NUMBER     : 70343-57-6
LAST UPDATED            : 199703
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C21-H22-N4-O6
MOLECULAR WEIGHT        : 426.47
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Antibiotic M83
   * 7-N-(p-Hydroxyphenyl)-mitomycin C
   * KW 2083
   * M-83
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GANNA2 Gann.  Japanese Journal of Cancer Research.  (Tokyo, Japan)  V.1-75,
   1907-84.  For publisher information, see JJCREP.  Volume(issue)/page/year:
   73,675,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 18800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CTSYEH Cancer Treatment Symposia.  (Cancer Chemotherapy Center, Japanese
   Foundation for Cancer Research, Kami-Ikebukuro, Toshima-ku, Tokyo 170,
   Japan)  V.1-    1983  Volume(issue)/page/year: 1,29,1983
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 3 umol/L
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 36,559,1983
 
                            *** END OF RECORD ***