*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CP8750000
CHEMICAL NAME           : Barbituric acid, 5-allyl-5-isobutyl-
CAS REGISTRY NUMBER     : 77-26-9
LAST UPDATED            : 199707
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C11-H16-N2-O3
MOLECULAR WEIGHT        : 224.29
WISWESSER LINE NOTATION : T6VMVMV FHJ F2U1 F1Y1&1
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Alisobumal
   * Allylbarbital
   * Allylbarbitone
   * Allylbarbituric acid
   * Allylisobutylbarbital
   * Allylisobutylbarbiturate
   * 5-Allyl-5-isobutylbarbituric acid
   * 5-Allyl-5-(2'-methyl-n-propyl) barbituric acid
   * Butalbarbital
   * Butalbital
   * Iso-butylallylbarbituric acid
   * Itobarbital
   * Optalidon
   * Profundal
   * 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(2-methylpropyl)-5-(2-propenyl)-
   * Sandoptal
   * Tetrallobarbital
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Vascular - BP lowering not characterized in autonomic section
   Lungs, Thorax, or Respiration - respiratory depression
   Gastrointestinal - nausea or vomiting
REFERENCE :
   SAVEAB Sammlung von Vergiftungsfaellen.  (Berlin, Germany)  V.1-13, 1930-44;
   V.14, 1952-54.  For publisher information, see ARTODN.
   Volume(issue)/page/year: 10,181A,1939
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Behavioral - toxic psychosis
   Behavioral - coma
   Kidney, Ureter, Bladder - other changes
REFERENCE :
   SAVEAB Sammlung von Vergiftungsfaellen.  (Berlin, Germany)  V.1-13, 1930-44;
   V.14, 1952-54.  For publisher information, see ARTODN.
   Volume(issue)/page/year: 10,209A,1939
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 160 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 152,341,1930
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - pigeon
DOSE/DURATION           : 75 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   21,315,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - duck
DOSE/DURATION           : 237 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   21,315,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - wild bird species
DOSE/DURATION           : 75 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   21,315,1972

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 80374
       No. of Facilities: 68 (estimated)
       No. of Industries: 1
       No. of Occupations: 6
       No. of Employees: 2770 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 80374
       No. of Facilities: 43 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 284 (estimated)
       No. of Female Employees: 144 (estimated)

 
                            *** END OF RECORD ***