*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CQ0477600
CHEMICAL NAME           : Barbituric acid, 1-benzoyl-5-ethyl-5-phenyl-
CAS REGISTRY NUMBER     : 744-80-9
BEILSTEIN REFERENCE NO. : 0627140
REFERENCE               : 5-24-09-00293 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C19-H16-N2-O4
MOLECULAR WEIGHT        : 336.37
WISWESSER LINE NOTATION : T6VMVNV FHJ DVR& F2 FR
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Benzobarbital
   * Benzonal
   * 1-Benzoyl-5-ethyl-5-phenylbarbituric acid
   * 1-Benzoyl-5-ethyl-5-phenyl-2,4,6-trioxohexahydropyrimidine
   * Benzoylluminal
   * Benzoylphenobarbital
   * Benzoyluminal
   * 2,4,6(1H,3H,5H)-Pyrimidinetrione, 1-benzoyl-5-ethyl-5-phenyl-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 982 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APSXAS Acta Pharmaceutica Suecica.  (Apotekarsocieteten-Farmacevtiska
   Foereningen, Box 1136, S-111, 81 Stockholm, Sweden)  V.1-    1964-
   Volume(issue)/page/year: 6,177,1969
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 20 mg/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   CYGEDX Cytology and Genetics (English Translation).  Translation of TGANAK.
   (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011)  V.8-    1974-
   Volume(issue)/page/year: 10(2),1,1976
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Dominant lethal test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 20 mg/kg
REFERENCE :
   CYGEDX Cytology and Genetics (English Translation).  Translation of TGANAK.
   (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011)  V.8-    1974-
   Volume(issue)/page/year: 10(2),1,1976

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative: Host-mediated assay
   
   EPA GENETOX PROGRAM 1988, Inconclusive: Rodent dominant lethal

 
                            *** END OF RECORD ***