*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : CQ3500000
CHEMICAL NAME : Barbituric acid, 5,5-diethyl-
CAS REGISTRY NUMBER : 57-44-3
BEILSTEIN REFERENCE NO. : 0163999
REFERENCE : 5-24-09-00137 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 24
MOLECULAR FORMULA : C8-H12-N2-O3
MOLECULAR WEIGHT : 184.22
WISWESSER LINE NOTATION : T6VMVMV FHJ F2 F2
COMPOUND DESCRIPTOR : Drug
Mutagen
SYNONYMS/TRADE NAMES :
* Barbital
* Barbitone
* DEBA
* Diemal
* Diethylbarbitone
* Diethyl-barbituric acid
* 5,5-Diethylbarbituric acid
* Diethylmalonylurea
* Dormonal
* Ethylbarbital
* Hypnogene
* Kyselina 5,5-diethylbarbiturova
* Malonal
* 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5,5-diethyl-
* Sedeval
* Uronal
* Veroletten
* Verolettin
* Veronal
* Vesperal
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 246 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year:
8,913,1953
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 152,341,1930
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,590,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 178 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
Italy) V.8-43 1953-88 For publisher information, see FRMCE8
Volume(issue)/page/year: 14,269,1959
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 630 mg/kg
TOXIC EFFECTS :
Behavioral - sleep
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - other changes
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15
Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-
Volume(issue)/page/year: 74,122,1954
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 250 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
Behavioral - rigidity (including catalepsy)
Behavioral - analgesia
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 33,43,1928
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 275 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 44,325,1932
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 225 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 44,325,1932
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JACSAT Journal of the American Chemical Society. (American Chemical Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.1- 1879- Volume(issue)/page/year: 45,243,1923
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPPGAR Journal de Physiologie et de Pathologie Generale. (Paris, France)
V.1-38, 1899-1945. For publisher information, see JOPHAN.
Volume(issue)/page/year: 30,364,1932
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 225 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville
Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year:
19,472,1939
** MUTATION DATA **
TYPE OF TEST : Morphological transformation
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 12600 mg/kg/6W
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 9,387,1988
TYPE OF TEST : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 100 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 343,157,1995
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 33 gm/kg
REFERENCE :
IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical
Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913-
Volume(issue)/page/year: 61,1568,1973
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 33 gm/kg
REFERENCE :
IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical
Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913-
Volume(issue)/page/year: 61,1568,1973
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 1 gm/L
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
Volume(issue)/page/year: 4,41,1980
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Fibroblast
DOSE/DURATION : 2 gm/L/48H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 48,337,1977
*** REVIEWS ***
TOXICOLOGY REVIEW
NEURAI Neurology. (Modern Medicine Pub., Inc., 1 E. First St., Duluth, MN
55802) V.1- 1951- Volume(issue)/page/year: 3,58,1953
TOXICOLOGY REVIEW
PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville
Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year:
19,472,1939
TOXICOLOGY REVIEW
FNSCA6 Forensic Science. (Lausanne, Switzerland) V.1-11, 1972-78. For pub
lisher information, see FSINDR. Volume(issue)/page/year: 2,67,1973
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84316
No. of Facilities: 605 (estimated)
No. of Industries: 3
No. of Occupations: 4
No. of Employees: 4834 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84316
No. of Facilities: 538 (estimated)
No. of Industries: 1
No. of Occupations: 5
No. of Employees: 11338 (estimated)
No. of Female Employees: 8933 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: In vivo cytogenetics-nonhuman bone
marrow
EPA GENETOX PROGRAM 1988, Negative: In vitro SCE-nonhuman
*** END OF RECORD ***