*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CQ6650000
CHEMICAL NAME           : Barbituric acid, 5-ethyl-1-methyl-5-phenyl-
CAS REGISTRY NUMBER     : 115-38-8
BEILSTEIN REFERENCE NO. : 0256144
REFERENCE               : 5-24-09-00294 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C13-H14-N2-O3
MOLECULAR WEIGHT        : 246.29
WISWESSER LINE NOTATION : T6VMVNV FHJ D1 F2 FR
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * Enfenemal
   * Enphenemal
   * N-Ethylmethylphenylbarbituric acid
   * 5-Ethyl-N-methyl-5-phenylbarbituric acid
   * 5-Ethyl-1-methyl-5-phenylbarbituric acid
   * 5-Ethyl-5-phenyl-N-methyl-bartituric acid
   * Isonal
   * Isonal (roussel)
   * Mebaral
   * Menta-bal
   * Mephobarbital
   * Mephobarbitone
   * Mephytal
   * Methyl-calminal
   * 1-Methyl-5-ethyl-5-phenylbarbituric acid
   * Methylphenobarbital
   * N-Methylphenobarbital
   * 1-Methylphenobarbital
   * Methylphenobarbitone
   * N-Methylphenolbarbitol
   * Methylphenylbarbituric acid
   * N-Methyl-5-phenyl-5-ethylbarbital
   * 1-Methyl-5-phenyl-5-ethylbarbituric acid
   * Metylfenemal
   * Metyna
   * Morbusan
   * Phemetone
   * Phemiton
   * Phemitone
   * 5-Phenyl-5-ethyl-3-methylbarbituric acid
   * Prominal
   * 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-1-methyl-5-phenyl-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 130 mg/kg
TOXIC EFFECTS :
   Behavioral - anticonvulsant
REFERENCE :
   PHMCAA Pharmacologist.  (American Soc. for Pharmacology and Experimental
   Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014)  V.1-    1959-
   Volume(issue)/page/year: 5,237,1963
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HPPAAL Helvetica Physiologia et Pharmacologica Acta.  (Basel, Switzerland)
   V.1-26, 1943-68. Discontinued.  Volume(issue)/page/year: 19,241,1961
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 230 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,851,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,851,1982
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE                    : 3360 mg/kg
SEX/DURATION            : female 1-40 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - cardiovascular
   (circulatory) system
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 2,839,1972

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 84700
       No. of Facilities: 68 (estimated)
       No. of Industries: 1
       No. of Occupations: 6
       No. of Employees: 2770 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 84700
       No. of Facilities: 10 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 340 (estimated)
       No. of Female Employees: 180 (estimated)

 
                            *** END OF RECORD ***