*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CU3350000
CHEMICAL NAME           : Benz(c)acridine-7-carboxylic acid, 5,6-dihydro-
CAS REGISTRY NUMBER     : 83-93-2
BEILSTEIN REFERENCE NO. : 0256492
REFERENCE               : 4-22-00-01422 (Beilstein Handbook Reference)
LAST UPDATED            : 199709
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C18-H13-N-O2
MOLECULAR WEIGHT        : 275.32
WISWESSER LINE NOTATION : T D6 C666 BN&T&&J MVQ
SYNONYMS/TRADE NAMES :
   * 5,6-Dihydrobenz(c)acridine-7-carboxylic acid
   * Tetrofan
   * Tetrophan
   * Tetrophine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 760 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 113,27,1955
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Vascular - BP lowering not characterized in autonomic section
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 113,27,1955
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Behavioral - tetany
   Cardiac - other changes
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 113,371,1955
 
                            *** END OF RECORD ***