*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CU8702300
CHEMICAL NAME           : Benzamide,
                          4-(acetyloxy)-N-(2,4-dibromo-6-((cyclohexylmethylamin
                          o)methyl)phenyl)-3-me thoxy-, monohydrochloride
CAS REGISTRY NUMBER     : 54340-60-2
LAST UPDATED            : 199703
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C24-H28-Br2-N2-O4.Cl-H
MOLECULAR WEIGHT        : 604.82
SYNONYMS/TRADE NAMES :
   * BR-222
   * Brovanexine hydrochloride
   * UR 389
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >12 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EPXXDW European Patent Application. (U.S. Patent and Trademark Office,
   Foreign Patents, Washington, DC 20231)  Volume(issue)/page/year: #0061157
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Behavioral - antipsychotic
   Lungs, Thorax, or Respiration - dyspnea
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 25,603,1983
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 25,603,1983
 
                            *** END OF RECORD ***