*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CV3433000
CHEMICAL NAME           : Benzamide,
                          N-(decahydro-2-methyl-5-isoquinolyl)-3,4,5-trimethoxy
                          -, trans-
CAS REGISTRY NUMBER     : 27460-73-7
LAST UPDATED            : 199007
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C20-H30-N2-O4
MOLECULAR WEIGHT        : 362.52
WISWESSER LINE NOTATION : T66 CNTJ C1 GMVR CO1 DO1 EO1
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Benzamide, N-(2-methyldecahydroisoquinol-5-yl)-3,4,5-trimethoxy-, (E)-
   * trans-N-(Decahydro-2-methyl-5-isoquinolyl)-3,4,5-trimethoxybenzamide
   * M-32
   * trans-N-(2-Methyldecahydroisoquinol-5-yl)-3,4,5-trimethoxybenzamide
   * 5-(3,4,5-Trimethoxybenzamido)-2-methyl-trans-decahydroisoquinoline
   *   trans-9,10-t-5-H-5-(3,4,5-Trimethoxybenzamido)-2-methyldecahydroisoquino
     line
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 221 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 23,206,1980
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   DECRDP Drugs under Experimental and Clinical Research.  (Bioscience
   Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland)  V.1-    1977-
   Volume(issue)/page/year: 10,197,1984
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 17800 ug/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   DECRDP Drugs under Experimental and Clinical Research.  (Bioscience
   Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland)  V.1-    1977-
   Volume(issue)/page/year: 10,197,1984
 
                            *** END OF RECORD ***