*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CV5396000
CHEMICAL NAME           : Benzamide,
                          N-(1-(2-(1H-indol-3-yl)ethyl)-4-piperidinyl)-,
                          monohydrochloride
CAS REGISTRY NUMBER     : 38821-52-2
OTHER CAS REGISTRY NOS. : 33124-53-7
LAST UPDATED            : 199707
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C22-H25-N3-O.Cl-H
MOLECULAR WEIGHT        : 383.96
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Baratol (pharmaceutical)
   * N-(1-(2-(1H-Indol-3-yl)ethyl)-4-piperidinyl)benzamide hydrochloride
   * Indoramina
   * Indoramin hydrochloride
   * WY 21901
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 7 mg/kg/1W-I
TOXIC EFFECTS :
   Behavioral - wakefulness
   Behavioral - excitement
   Cardiac - pulse rate increase, without fall in BP
REFERENCE :
   PRACAK Practitioner.  (Morgan-Grampian Ltd., 40 Beresford St., Woolwich,
   London SE18 6BQ, UK) V.1-    1868-  Volume(issue)/page/year: 228,362,1984
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   43NDAD "Pharmacology of Antihypertensive Drugs," Scriabine, A., ed., New
   York, Raven Press, 1980  Volume(issue)/page/year: -,161,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   43NDAD "Pharmacology of Antihypertensive Drugs," Scriabine, A., ed., New
   York, Raven Press, 1980  Volume(issue)/page/year: -,161,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   43NDAD "Pharmacology of Antihypertensive Drugs," Scriabine, A., ed., New
   York, Raven Press, 1980  Volume(issue)/page/year: -,161,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   43NDAD "Pharmacology of Antihypertensive Drugs," Scriabine, A., ed., New
   York, Raven Press, 1980  Volume(issue)/page/year: -,161,1980
 
                            *** END OF RECORD ***