*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : CV6292000
CHEMICAL NAME : Benzamidine, p-(methylsulfonyl)-, hydrochloride
CAS REGISTRY NUMBER : 5434-06-0
LAST UPDATED : 198806
DATA ITEMS CITED : 3
MOLECULAR FORMULA : C8-H10-N2-O2-S.Cl-H
MOLECULAR WEIGHT : 234.72
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* Benzenecarboximidamide, 4-(methylsulfonyl)-, monohydrochloride
* p-Methylsulphonylbenzamidine hydrochloride
* V 187
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1200 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Vascular - BP lowering not characterized in autonomic section
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 84,160,1945
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
Volume(issue)/page/year: 2,523,1944
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 280 mg/kg
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 84,160,1945
*** END OF RECORD ***