*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : CV6500000
CHEMICAL NAME : Benzamidine, 4,4'-(pentamethylenedioxy)di-,
bis(beta-hydroxyethanesulfonate)
CAS REGISTRY NUMBER : 140-64-7
LAST UPDATED : 199603
DATA ITEMS CITED : 13
MOLECULAR FORMULA : C19-H24-N4-O2.C4-H12-O8-S2
MOLECULAR WEIGHT : 592.75
WISWESSER LINE NOTATION : MUYZR DO5OR DYZUM &WSQ2Q 2
COMPOUND DESCRIPTOR : Drug
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Diamidine
* 4,4'-Diamidinodiphenoxypentane di(beta-hydroxyethanesulfonate)
* 4,4'-Diamidino-alpha,omega-diphenoxypentane isethionate
* Lomidin
* Lomidine
* Lomidine isoethionate
* M & B 800
* Pentam 300
* 4,4'-(Pentamethylenedioxy)-dibenzamidine bis(2-hydroxyethanesulfonate)
* p,p'-(Pentamethylenedioxy)dibenzamidine bis(beta-hydroxyethanesulfonate)
* Pentamidine diisethionate
* Pentamidine isethionate
* 2512 R.P.
* R.P. 2512
* USAF XR-10
* WR 4931
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Human - man
DOSE/DURATION : 21429 ug/kg/5D-I
TOXIC EFFECTS :
Endocrine - hypoglycemia
Skin and Appendages - sweating
REFERENCE :
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200
Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year:
108,490,1988
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Human - man
DOSE/DURATION : 24 mg/kg/6D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - hematuria
REFERENCE :
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200
Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year:
105,146,1986
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Human - man
DOSE/DURATION : 68 mg/kg/17D-I
TOXIC EFFECTS :
Gastrointestinal - changes in structure or function of endocrine pancreas
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year:
256,2383,1986
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 6 mg/kg/D
TOXIC EFFECTS :
Blood - hemorrhage
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment
Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948-
Volume(issue)/page/year: 34,441,1974
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Human - man
DOSE/DURATION : 26 mg/kg/9D-I
TOXIC EFFECTS :
Endocrine - hypoglycemia
REFERENCE :
JTMHA9 Journal of Tropical Medicine and Hygiene. (Blackwell Scientific Pub.
Ltd., POB 88, Oxford, UK) V.10- 1907- Volume(issue)/page/year:
87,15,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 63 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 2,581,1952
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 120 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 2,581,1952
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 15100 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 2,581,1952
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 756 mg/kg/6W-I
TOXIC EFFECTS :
Gastrointestinal - changes in structure or function of endocrine pancreas
Liver - changes in liver weight
Related to Chronic Data - death
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
Japan) V.1- 1950- Volume(issue)/page/year: 41,137,1990
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 112 mg/kg/2W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
Related to Chronic Data - death
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
Japan) V.1- 1950- Volume(issue)/page/year: 41,137,1990
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE : 24 mg/kg
SEX/DURATION : female 6-11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-
Volume(issue)/page/year: 163,912,1990
** MUTATION DATA **
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Rodent - mouse Leukocyte
DOSE/DURATION : 29500 ug/L
REFERENCE :
INNDDK Investigational New Drugs. The Journal of New Anticancer Agents.
Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018) V.1- 1983-
Volume(issue)/page/year: 1,103,1983
*** STATUS IN U.S. ***
NIOSH Analytical Method, 1994: Pentamidine isethionate, 5032
*** END OF RECORD ***