*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CV6520000
CHEMICAL NAME           : Benzamidine, 4,4'-(pentamethylenedioxy)di-,
                          dihydrochloride
CAS REGISTRY NUMBER     : 50357-45-4
LAST UPDATED            : 199712
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C19-H24-N4-O2.2Cl-H
MOLECULAR WEIGHT        : 413.39
WISWESSER LINE NOTATION : MUYZR DO5OR DYZUM &GH 2
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 4,4'-Diamidino-1,5-diphenoxypentane dihydrochloride
   * Pentamidine dihydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 64 mg/kg
TOXIC EFFECTS :
   Brain and Coverings - recordings from specific areas of CNS
   Lungs, Thorax, or Respiration - other changes
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   ATMPA2 Annals of Tropical Medicine and Parasitology.  (Grune & Stratton,
   Inc., POB 6280, Duluth, MN 55806)  V.1-    1907-  Volume(issue)/page/year:
   37,1,1943
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 28 mg/kg
TOXIC EFFECTS :
   Brain and Coverings - recordings from specific areas of CNS
   Lungs, Thorax, or Respiration - other changes
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   ATMPA2 Annals of Tropical Medicine and Parasitology.  (Grune & Stratton,
   Inc., POB 6280, Duluth, MN 55806)  V.1-    1907-  Volume(issue)/page/year:
   37,1,1943
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 128 mg/kg/10D-I
TOXIC EFFECTS :
   Vascular - regional or general arteriolar or venous dilation
   Lungs, Thorax, or Respiration - respiratory depression
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   ATMPA2 Annals of Tropical Medicine and Parasitology.  (Grune & Stratton,
   Inc., POB 6280, Duluth, MN 55806)  V.1-    1907-  Volume(issue)/page/year:
   37,1,1943
 
                            *** END OF RECORD ***