*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : CW5075000
CHEMICAL NAME : Benz(a)anthracene, 5,6-epoxy-5,6-dihydro-7-methyl-
CAS REGISTRY NUMBER : 1155-38-0
LAST UPDATED : 199503
DATA ITEMS CITED : 19
MOLECULAR FORMULA : C19-H14-O
MOLECULAR WEIGHT : 258.33
WISWESSER LINE NOTATION : T B3 G6 E666 COT&&T&J F1
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Benz(a)anthracene, 5,6-dihydro-5,6-epoxy-7-methyl-
* 5,6-Epoxy-5,6-dihydro-7-methylbenz(a)anthracene
* 7-Methylbenz(a)anthracene 5,6 oxide
*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 120 mg/kg/20W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
Tumorigenic - tumors at site of application
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 124,915,1967
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 400 mg/kg/10W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966-
Volume(issue)/page/year: 2,500,1967
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 43 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 124,915,1967
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 500 ng/plate
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
45,2600,1985
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 100 pmol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 324,111,1994
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 100 umol/L
REFERENCE :
ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin,
Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see JCROD7.
Volume(issue)/page/year: 92,157,1978
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 1 mmol/L
REFERENCE :
ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin,
Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see JCROD7.
Volume(issue)/page/year: 92,157,1978
TYPE OF TEST : DNA damage
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 6600 umol/L
REFERENCE :
ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin,
Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see JCROD7.
Volume(issue)/page/year: 90,37,1977
TYPE OF TEST : Phage inhibition capacity
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 17900 nmol/L
REFERENCE :
NNBYA7 Nature (London), New Biology. (Basingstoke, Hants., UK) V.229-246,
1971-73. For publisher information, see NATUAS. Volume(issue)/page/year:
234,186,1971
TYPE OF TEST : Specific locus test
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 5 mmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
33,2354,1973
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 5 mmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
33,2354,1973
TYPE OF TEST : DNA adduct
TEST SYSTEM : Fish - salmon Sperm
DOSE/DURATION : 100 mg/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
33,2386,1973
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - mouse Fibroblast
DOSE/DURATION : 50 ug/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
32,716,1972
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Rodent - mouse Embryo
DOSE/DURATION : 1 mg/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
36,2306,1976
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - hamster Kidney
DOSE/DURATION : 5 mg/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year:
20,1297,1971
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: SHE-clonal assay; Cell transform.-mouse
prostate
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
*** END OF RECORD ***